Harman and Norharman Suppressed but NaNO_2 Enhanced the Development of Preneoplastic Liver Cell Foci in 2-Amino-3,8-Dimethylimidazo[4,5-f]Quinoxaline (MeIQx)-Treated Rats
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概要
- 論文の詳細を見る
The modifying potentials of two heterocyclic amines, harman and norharman, as well as sodium nitrite (NaNO2), on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced rat liver carcinogenesis were investigated using a medium-term liver bioassay system. Harman (500 ppm in diet), norharman (500 ppm in diet) or NaNO2 (0.1% in drinking water) were given with or without MeIQx (300 ppm in diet) for 6 weeks after initiation with a single dose of dimethylnitrosamine (DEN). The appearance of MeIQx-induced glutathione S-transferase placental form positive foci in the liver was significantly decreased in the harman and norharman cases (p< 0.001), but it was significantly increased by NaNO2 (p< 0.001). These chemicals, however, did not modify DEN-liver carcinogenesis in the absence of MeIQx. Neither harman nor norharman affected mRNA expression of CYP1A1 and 1A2 in the liver, with or without MeIQx administration, whereas NaNO2 significantly enhanced CYP1A1 mRNA levels together with MeIQx.
- 日本毒性病理学会の論文
- 2005-06-30
著者
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Hirose Masao
Division of Pathology, National Institute of Health Sciences
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SHIRAI Tomoyuki
Department of Pathology, Nagoya City University Medical School
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Tamano S
Dims Institute Of Medical Science Inc.
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ASAMOTO Makoto
Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Me
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Shirai T
Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya City University
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Asamoto M
Department Of Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya Ci
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Asamoto M
Department Of Experimental Pathology And Tumor Biology Nagoya City University Graduate School Of Med
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Asamoto Makoto
国立がんセンター
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Asamoto Makoto
住友製薬大阪研究所
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HOKAIWADO Naomi
Department of Experimental Pathology and Tumor Biology, Nagoya City University, Graduate School of M
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Hirose Masao
Division Of Pathology National Institute Of Health Sciences
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Mutai Mamoru
First Department Of Pathology Nagoya City University Medical School
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SHIRAI Tomoyuki
Nagoya City University Medical School
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SUGIURA Satoshi
Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Me
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Shirai Tomoyuki
Graduate School Of Medical Sciences Nagoya City University
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Hokaiwado Naomi
Department Of Experimental Pathology And Tumor Biology Nagoya City University Graduate School Of Med
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Hokaiwado Naomi
Experimental Pathology And Chemotherapy Division National Cancer Center Research Institute
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Shirai Tomoyuki
Department Of Biochemistry Niigata College Of Pharmacy
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Shirai T
大雄会医科学研究所
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Asamoto Makoto
Department Of Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya Ci
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Sugiura Satoshi
Department Of Experimental Pathology And Tumor Biology Nagoya City University Graduate School Of Med
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Sugiura Satoshi
Department Of Agricultural Chemistry Faculty Of Agriculture University Of Tottori
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Shirai Tomoyuki
Pathology Group Yakult Central Inst.
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