Combined Chemopreventive Effects of Perilla or Corn Oil and Indomethacin in a Rat Medium-Term Multiorgan Carcinogenesis Model

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概要

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• The effects of n-3 α-linolenic acid-rich perilla oil (P-oil) or n-6 linoleic acid-rich corn oil (C-oil) and indomethacin (IM), either alone or in combination, were examined in a rat medium-term multiorgan carcinogenesis model. Male F344 rats were given N-diethylnitrosamine (DEN), N-methyl-nitrosourea (MNU), N-butyl- N-(4-hydroxybutyl) nitrosamine (BBN), N-nitrosobis (2-hydroxypropyl) amine (DHPN) and 1,2- dimethylhydrazine (DMH) during the initial 4 weeks as initiators. This was followed by additional of 10% each of P-oil or C-oil to each their diet, alone or with IM 40 ppm in their drinking water for, 32 weeks. The animals were sacrificed at week 36, and proliferative lesions in major organs, such as the liver, kidney, lung and colon, were examined histopathologically. IM significantly lowered the multiplicity of colon tumors. P-oil tended to lower the incidences and multiplicities of colon tumors while C-oil tended to increase them. Additional treatment with IM caused further decreases in animals receiving P-oil, but the effect was less than additive. In the C-oil group, additional treatment with IM nullified its enhancing effect. In the lung, C-oil weakly increased the incidence and multiplicity of lung tumors. However, this was again suppressed by additional treatment with IM. While perilla oil and IM alone did not influence lung and renal carcinogenesis, their combination again enhanced carcinogenesis in the lung and kidney. In the liver, P-oil or C-oil alone significantly decreased the number and/or area of GST-P positive foci, while additional treatment with IM tended to nullify the decrease. These results suggest that IM exerts different modifying effects in the presence of different fats in the diet.

• 日本毒性病理学会の論文
• 2007-12-25

著者

• Hirose Masao

  Division of Pathology, National Institute of Health Sciences

• 高橋 智

  首都大学東京 大学院理工学研究科機械工学専攻

• SHIRAI Tomoyuki

  Department of Pathology, Nagoya City University Medical School

• Tamano S

  Dims Institute Of Medical Science Inc.

• KAWABE Mayumi

  DIMS Institute of Medical Science, Inc.

• FUTAKUCHI Mitsuru

  Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya

• Shirai T

  Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya City University

• Shirai Tomoyuki

  ボゾリサーチセンター御殿場研究所

• Kawabe Mayumi

  Dims Inst. Of Medical Sci. Inc.

• Kawabe Mayumi

  名古屋市立大学 医学研究科第一病理学

• Kawabe Mayumi

  Dims Inst. Medical Sci. Inc.

• Kawabe Mayumi

  三省製薬

• Futakuchi M

  Department Of Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya Ci

• Futakuchi Mitsuru

  米国

• Futakuchi Mitsuru

  Department Of Pathology And Microbiology University Of Nebraska Medical Center

• Futakuchi Mitsuru

  First Department Of Pathology Nagoya City University Medical School

• Hirose M

  Division Of Pathology National Institute Of Health Sciences:food Safety Commission

• Hirose Masao

  名古屋市立大学 医学研究科実験病態病理学

• SATO Shinya

  Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya

• YAMAGUCHI Tsuyoshi

  Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya

• Kuribayashi Masanori

  名古屋市立大学 医学研究科実験病態病理学分野

• Hoshi Manabu

  大阪市立大学 医学部病理学

• Sugimura T

  Cancer Prevention Basic Research Project National Cancer Center Research Institute

• Hirose Masao

  Division Of Pathology National Institute Of Health Sciences

• Sato Shinya

  Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya City University

• Shimokawa T

  National Cancer Center Res. Inst. Tokyo Jpn

• SHIRAI Tomoyuki

  Nagoya City University Medical School

• Shirai Tomoyuki

  Graduate School Of Medical Sciences Nagoya City University

• Hosono M

  Aburahi Laboratories Shionogi Research Laboratories Shionogi Co Ltd.

• Takahashi S

  Department Of Experimental Pathology And Tumor Biology Nagoya City University Graduate School Of Med

• Yamaguchi Tsuyoshi

  Department Of Applied Veterinary Sciences United Graduate School Of Veterinary Sciences Gifu Univers

• Hirose Masao

  First Department Of Pathology Nagoya City University Medical School

• Hirose Masao

  Department Of Pathology Nagoya Higashi Municipal Hospital

• Shirai Tomoyuki

  Department Of Biochemistry Niigata College Of Pharmacy

• Shirai T

  大雄会医科学研究所

• Tamano Seiko

  First Department Of Pathology Nagoya City University Medical School

• Yamane Tetsuro

  The First Department Of Surgery Kyoto Prefectural University Of Medicine

• Yamaguchi T

  Department Of Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya Ci

• Sugimura T

  Carcinogenesis Division National Cancer Center Research Institute

• Shirai Tomoyuki

  Pathology Group Yakult Central Inst.

• Shirai Tomoyuki

  Nagoya City Univ. Postgraduate School Of Medical Sci. Nagoya

• Mori Hideki

  First Department Of Pathology Gifu University School Of Medicine

• Yamaguchi Tsuyoshi

  Department Of Applied Physics Faculty Of Engineering Shizuoka University

• Sato Shinya

  Department Of Animal Science Tokyo University Of Agriculture

• Tamano Seiko

  Daiyu-kai Institute Of Medical Science

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