Gene Expression Profiling and Cellular Distribution of Molecules with Altered Expression in the Hippocampal CA1 Region after Developmental Exposure to Anti-Thyroid Agents in Rats
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概要
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To determine whether developmental hypothyroidism causes permanent disruption of neuronal development, we first performed a global gene expression profiling study targeting hippocampal CA1 neurons in male rats at the end of maternal exposure to anti-thyroid agents on weaning (postnatal day 20). As a result, genes associated with nervous system development, zinc ion binding, apoptosis and cell adhesion were commonly up- or down-regulated. Genes related to calcium ion binding were up-regulated and those for myelination were often down-regulated. We, then, examined immunohistochemical cellular distribution of Ephrin type A receptor 5 (EphA5) and Tachykinin receptor (Tacr)-3, those selected based on the gene expression profiles, in the hippocampal formation at the adult stage (11-week-old) as well as at the end of exposure. At weaning, both EphA5- and Tacr3-immunoreactive cells with strong intensities appeared in the pyramidal cell layer or stratum oriens of the hippocampal CA1 region. Although the magnitude of the change was decreased at the adult stage, Tacr3 in the CA1 region showed a sustained increase in expressing cells until the adult stage after developmental hypothyroidism. On the other hand, EphA5-expressing cells did not show sustained increase at the adult stage. The results suggest that developmental hypothyroidism caused sustained neuronal expression of Tacr3 in the hippocampal CA1 region, probably reflecting a neuroprotective mechanism for mismigration.
- 社団法人 日本獣医学会の論文
著者
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SAEGUSA Yukie
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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SHIBUTANI Makoto
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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MITSUMORI Kunitoshi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Hirose Masao
Division of Pathology, National Institute of Health Sciences
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Nishikawa Akiyoshi
Division of Pathology, National Institute of Health Sciences
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KANNO Jun
Division of Cellular and Molecular Toxicology, Kangwon National University
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TAKAHASHI Miwa
Division of Pathology, National Institute of Health Sciences
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IGARASHI Katsuhide
Division of Cellular and Molecular Toxicology, BSRC, National Institute of Health Sciences
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Hirose Masao
Division Of Pathology National Institute Of Health Sciences
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Mitsumori Kunitoshi
Laboratory Of Veterinary Pathology Division Of Animal Science Institute Of Symbiotic Science And Tec
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Inoue Kaoru
Division Of Pathology National Institute Of Health Sciences
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Saegusa Yukie
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Takahashi Miwa
Division Of Pathology National Institute Of Health Sciences
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Nishikawa Akiyoshi
Division Of Pathology Biology Safety Research Center National Institute Of Health Sciences
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WOO Gye-Hyeong
Division of Pathology, National Institute of Health Sciences
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FUJIMOTO Hitoshi
Division of Pathology, National Institute of Health Sciences
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Shibutani Makoto
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Igarashi Katsuhide
Division Of Cellular & Molecular Toxicology Biological Safety Research Center National Institute
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Kanno Jun
Division Of Cellular & Molecular Toxicology Biological Safety Research Center National Institute
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