No Modifying Effect of Antioxidant N-Acetyl-L-Cysteine on Fenofibrate-induced Hepatocarcinogenesis in Rats
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概要
- 論文の詳細を見る
To clarify the modifying effect of N-Acetyl-L-Cysteine (NAC), which has antioxidative ability, on hepatocarcinogenesis promoted by fenofibrate (FF), a peroxisome proliferator-activated receptor (PPAR) alpha agonist, male F344/N rats were administered a single intraperitoneal injection of N-diethylnitrosamine (DEN) as an initiator followed by administration of a diet containing 3,000 ppm of FF for 16 weeks. Two-thirds partial hepatectomy was performed 1 week after the FF treatment. Additionally, NAC treatments for 14 weeks from 2 weeks after the FF treatment were performed. Although the expression level of tumor protein p53 (Tp53) mRNA decreased in the DEN+FF+NAC group as compared with that in the DEN+FF group, no significant differences between the DEN+FF and DEN+FF+NAC groups were observed in the number of hepatocellular altered foci and activities of hepatocellular proliferation. In addition, the results of an antioxidant enzyme assay and measurement of the amounts of total glutathione in the liver revealed no significant difference between the DEN+FF and DEN+FF+NAC groups; although no significant differences were observed in many genes between the DEN+FF and DEN+FF+NAC groups, only glutathione peroxidase 2 (Gpx2) mRNA increased in the DEN+FF+NAC group as compared with the DEN+FF group. The results under the present experimental conditions indicate no obvious modifying effect of NAC on liver tumor promotion by FF in rats.
- 日本毒性病理学会の論文
著者
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DEWA Yasuaki
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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KAWAI Masaomi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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NISHIMURA Jihei
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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SAEGUSA Yukie
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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KEMMOCHI Sayaka
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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HARADA Tomoaki
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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SHIBUTANI Makoto
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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MITSUMORI Kunitoshi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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SHIMA Tomomi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Dewa Yasuaki
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Dewa Yasuaki
東京農工大学 獣医病理学
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Jin Meilan
Division Pathology, Biological Safety Research Center, National Institute of Health Sciences
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Mitsumori Kunitoshi
Laboratory Of Veterinary Pathology Division Of Animal Science Institute Of Symbiotic Science And Tec
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Shima Tomomi
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Saegusa Yukie
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Kawai Masaomi
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Harada Tomoaki
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Shibutani Makoto
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Shimamoto Keisuke
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Itoh Tadashi
Hashima Laboratory, Nihon Bioresearch Inc.
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Nishimura Jihei
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Nishimura Jihei
Laboratory Of Applied Physiology Faculty Of Agriculture Kobe University Graduate School Of Science A
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Kemmochi Sayaka
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Shimamoto Keisuke
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Jin Meilan
Division Of Pathology National Institute Of Health Sciences
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