In vivo genotoxicity of 1-methylnaphthalene from comprehensive toxicity studies with B6C3F1 gpt delta mice

スポンサーリンク

概要

• 論文の詳細を見る
• 2012-08-01

著者

• Umemura T

  Division Of Pathology National Institute Of Health Sciences

• ISHII Yuji

  Division of Pathology, National Institute of Health Sciences

• Nishimura T

  Division Of Environmental Chemistry

• Jin Meilan

  Division Pathology, Biological Safety Research Center, National Institute of Health Sciences

• Ishii Yuji

  Division Of Pathology National Institute Of Health Sciences

• Suzuki Yuta

  Division Of Pathology National Institute Of Health Sciences

• Nishikawa A

  Div. Of Pathology National Inst. Of Health Sciences

• Nishikawa A

  National Inst. Health Sci. Tokyo Jpn

• Nishikawa A

  National Institute Of Health Science Osaka Branch National Institute Of Health Sciences

• Suzuki Yuta

  Division Of Cardiology Department Of Medicine Keio University School Of Medicine

• Umemura Takashi

  Division Of Pathology National Institute Of Health Sciences

• Nishikawa Akiyoshi

  Biological Safety Research Center, National Institute of Health Sciences

• Unno Takashi

  Division Of Pathology National Institute Of Health Sciences

• Umemura T

  Hokkaido Univ. Sapporo Jpn

• Umemura Takashi

  Division Of Pathology National Institute Of Health Science

• Unno Takashi

  Japan Pharmaceutical Manufactures Association (jpma):kanebo Ltd

• Ogawa Kumiko

  Division of Pathology, National Institute of Health Sciences

• Hibi Daisuke

  Division of Pathology, National Institute of Health Sciences

• Hibi Daisuke

  Division Of Pathology National Institute Of Health Sciences

• Umemura Takashi

  Laboratory Of Comparative Pathology Graduate School Of Veterinary Medicine Hokkaido University

• Nishikawa Akiyoshi

  Division Of Pathology Nihs

• Ishii Yuji

  Division Of Pathology National Institute Of Health Science

• KIJIMA Aki

  Division of Pathology, National Institute of Health Sciences

• NOHMI Takehiko

  Sciences of Genome Safety, National Institute of Health Sciences

• Kijima Aki

  Division Of Pathology National Institute Of Health Sciences

• Nohmi Takehiko

  Sciences Of Genome Safety National Institute Of Health Sciences

• Jin Meilan

  Division Of Pathology National Institute Of Health Sciences

• Ogawa Kumiko

  Division Of Pathology National Institute Of Health Sciences

関連論文

• A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats
• A Mixed Apocrine Gland Tumor with Metastases to the Bone and Bone Marrow in a Miniature Poodle
• Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide
• Lack of modifying effects of prepubertal exposure to acrylamide (AA) on N-methyl-N-nitrosourea (MNU)-induced multi-organ carcinogenesis in F344 rats
• Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
• Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
• Rapid Screening for Chemopreventive Agents in Herbal Extracts in a PhIP Rat Model with DNA Adduct and Cell Proliferation as End-Points
• DNA Adduct Formation, Nucleolar Segregation and Cell Proliferation in Rats Treated with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
• In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate
• Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
• In vivo mutagenicity and oxidative DNA damage in the livers of gpt delta mice treated with flumequine(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
• Catechol enhanced mice hepatotoxicity treated with acetaminophen(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
• Lack of Initiating Activity of Kojic Acid on Hepatocarcinogenesis in F344 Rats
• Electron Microscopical Evidence of the Protective Function of Thioredoxin (TRX/ADF) Transgene against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced Cellular Toxicity in the Liver and Brain
• P8-27 Susceptibility to pentachlorophenol, a mouse liver carcinogen in Nrf2-deficient mice(CIRCULATORY SYSTEM-2/ACTIVE OXYGEN)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
• Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
• P6-43 Screening of chemopreventive agents using a medium-term pancreas carcinogenesis model in hamsters(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
• Dose-related changes of oxidative stress and cell proliferation in kidneys of male and female F344 rats exposed to potassium bromate
• Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl) nitrosamine in rats after initiation
• A possible role of oxidative stress in potassium bromate (KBrO_3) carcinogenesis (ACTIVE OXYGEN) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl) nitrosamine
• Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis : Results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine
• Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
• In vivo Approaches to Study Mechanism of Action of Genotoxic Carcinogens
• Mechanistic study on hepatocarcinogenesis induced by dicyclanil in mice : possible involvement of oxidative stress(Proceedings of the 32nd Annual Meeting)
• The Mouse rasH2/BHT Model as an in vivo Rapid Assay for Lung Carcinogens
• Enhancement by Cigarette Smoke Exposure of 2-Amino-3,8-dimethylimidazo [4,5-f] quinoxaline-induced Rat Hepatocarcinogenesis in Close Association with Elevation of Hepatic CYP1A2
• Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
• Prevention by 2-Mercaptoethane Sulfonate and N-Acetylcysteine of Renal Oxidative Damage in Rats Treated with Ferric Nitrilotriacetate
• 3A-08 A Chronic Inhalation Study of p-Dichlorobenzene in the F344 Rat
• Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
• PE-196 Differences in central sleep apnea in right and left heart disorders(Heart failure, clinical(08)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
• A SURVEY OF THE VALUES OF CLINICAL CHEMISTRY PARAMETERS OBTAINED FOR A COMMON RAT BLOOD SAMPLE IN NINETY-EIGHT JAPANESE LABORATORIES
• Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
• Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice
• Involvement of Lipid Peroxidation in Spontaneous Pancreatitis in WBN/Kob Rats
• "P-22 A Combination Toxicity Study of Sodium Ascorbate and Sodium Nitrite In Rats
• REVISION AND ESTABLISHMENT OF JAPANESE DRINKING WATER QUALITY GUIDELINES FOR DI(2-ETHYLHEXYL) PHTHALATE, TOLUENE AND VINYL CHLORIDE : DIFFERENCES FROM THE LATEST WHO GUIDELINE DRAFTS
• Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model
• Long-Term Treatment with Bromocriptine Inhibits Endometrial Adenocarcinoma Development in Rats
• Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods-a preliminary study
• SUPPRESSING EFFECT OF CROTON OIL ON INTESTINAL CARCINOGENESIS INDUCED BY METHYLAZOXYMETHANOL ACETATE IN RATS
• LACK OF PROMOTIVE EFFECT OF QUERCETIN ON METHYLAZOXYMETHANOL ACETATE CARCINOGENESIS IN RATS
• TOXICITY STUDY OF A RUBBER ANTIOXIDANT, 2-MERCAPTOBENZIMIDAZOLE, BY REPEATED ORAL ADMINISTRATION TO RATS
• Left Ventricular Apical Thrombus Formation in a Patient With Suspected Tako-Tsubo-Like Left Ventricular Dysfunction
• A 13-WEEK TOXICITY STUDY OF SIMULTANEOUS ADMINISTRATION OF COCHINEAL AND ALUMINUM POTASSIUM SULFATE IN RATS
• Impaired Myelinogenesis and Early Maturation of Oligodendrocytes in Black Tremor Hamster with Central Nervous System Myelin Deficiency
• Sustained hypomyelination and high serum thyroid hormone in aged black tremor hamster
• "P-12 The effects of 90-day feeding of Aramite or other herbicides of diphenyl ether group on livers, gall-bladders and bile ducts in dogs.
• Sample surveillance for clinical pathology testing.
• B-22 A 28-DAY REPEATED DOSE TOXICITY TEST AND THE TIME COURSE OF CHOLINESTERASE ACTIVITY TEST FOR CHLORPYRIFOS IN WISTAR RAT
• B38 COMPARISON OF TOXICITY OF p-DCB IN MALE AND FEMALE RATS
• Genetic and morphological differentiation in the hermatypic coral Galaxea fascicularis in Okinawa, Japan
• "P-35 Contribution of Oxidative Stress to Rat Hepatotoxicity induced by 2-Nitropropane : Lipid Peroxidation and Inhibitory Effect of Green Tea.
• COMRARISON OF TOXICITY OF p-DICHLOROBENZENE (p-DCB) GIVEN ORALLY AND BY INHALATION
• O-55 HEMATOTOXICICOLOGIC CHARACTERISTICS FOR OXIDATIVE STRESSES INTRANSGENIC AND/OR KNOCK-OUT MICE FOR THIOREDOXIN/ADF GENE.(Proceedings of the 27th Annual Meeting)
• 21B-10-4 Benzene hemopoietic toxicity revisited- a new concept.
• 3A-09 Hemopoietic Stem-Cell Kinetics Evaluated by Bromodeoxyuridine Incorporation Followed by Near-UV Exposure to Kill Cycling Stem Cells (BUUV). 2) Bone Marrow Cells from Mice Carrying Human c-myc Proto-Oncogene with Promoters Combined with Immunoglobuli
• "P-8 Experimental myelodysplasia induced by Azidothymidine (AZT) : Hemopoietic Stem Cell Kinetics And Pathological Findings.
• Sample surveillance for clinical pathology testing(2) Analysis of blood chemical data
• P-75 Toxicity evaluation of a strong mutagen MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone) in drinking water.(Proceedings of the 27th Annual Meeting)
• 28-DAY REPEATED-DOSE ORAL TOXICITY STUDY OF 2-MERCAPTOBENZIMIDAZOLE, A RUBBER ANTIOXIDANT, IN RATS
• A 14-WEEK ORAL TOXICITY STUDY OF TRIBUTOXYETHYL PHOSPHATE(TBEP) IN RATS
• Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
• "B-3 Toxicokinetic Study of 2-Mercaptobenzimidazole (MBI) and its Methylated Derivative (MMBI) in Rats after Single Oral-Dose Administration.
• Inhibitory effects of aminoguanidine on thyroid follicular carcinoma development in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation
• Intracoronary Administration of Nicorandil for the Treatment of Spontaneous Microvascular Spasm With ST Segment Elevation
• No Modifying Effect of Antioxidant N-Acetyl-L-Cysteine on Fenofibrate-induced Hepatocarcinogenesis in Rats
• 22D-11-3 Increased Liver and Kidney Toxicities in Rats Caused by Co-administration of 2-Mercaptobenzimidazole (MBI) and Lipopolysaccharide (LPS) and Their Toxicokinetics (TK).
• Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassay
• Chronic cadmium treatment induces islet B cell injury in ovariectomized cynomolgus monkeys
• P10-16 Increased osteoid volume and iron deposition of the Iumbar vertebra in a chronic cadmium toxicosis model of cynomolgus monkeys.
• 21D-04-1 Quantitative Analysis of Bone Lesion in Ovariectomized Cynomolgus Monkeys Given Repeated Intravenous Injections of CdCl_2.
• Comparison of Antibody Titers in Rabbits Following Immunization with Inactivated Influenza Virus via Subarachnoidal or Subcutaneous Route
• Efficacy of Intracerebral Immunization against Pseudorabies Virus in Mice
• In vitro demonstration of neural transmission of avian influenza A virus
• Laboratory of Comparative Pathology
• The Effects of a Vitamin D-deficient Diet on Chronic Cadmium Exposure in Rats
• ACUTE TOXICITY OF CADMIUM IN RATS WITH OR WITHOUT CADMIUM PRETREATMENT
• 302 EFFECTS OF CADMIUM CHLORIDB ON THE BLOOD AND URINARY EXAMINATIONS IN OVARIECTOMIZED RATS
• Oxidative DNA damage and reporter gene mutation in the livers of gpt delta rats given non-genotoxic hepatocarcinogens with cytochrome P450-inducible potency
• Effect of Intraaortic Balloon Pumping on Left Ventricular Function in Patients With Persistent ST Segment Elevation After Revascularization for Acute Myocardial Infarction
• Does Coronary Stenting Affect Microvascular Circulation in Patients With Anterior Acute Myocardial Infarction? : Comparison With Balloon Angioplasty
• Usefulness of Massive Oral Nicorandil in a Patient with Variant Angina Refractory to Concentional Treatment
• Lack of chronic toxicity and carcinogenicity of dietary administrated catechin mixture in Wistar Hannover GALAS rats
• Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats
• Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats
• Estrogen and androgen receptor status in hepatocellular hypertrophy induced by phenobarbital, clofibrate, and piperonyl butoxide in F344 rats
• Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action
• Toxic effects of a horseradish extract and allyl isothiocyanate in the urinary bladder after 13-week administration in drinking water to F344 rats
• Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats
• In vivo genotoxicity of 1-methylnaphthalene from comprehensive toxicity studies with B6C3F1 gpt delta mice
• Female heterozygous (+/fa) Zucker rats as a novel leptin-related mammary carcinogenesis model
• Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
• Reporter gene mutation in the livers of gpt delta mice treated with 5-(hydroxymethyl)-2-furfural, a contaminant of various foods
• Undifferentiated Sarcoma of the Salivary Gland in a Mongolian Gerbil (Meriones unguiculatus)
• Rhabdomyosarcoma in the Abdominal Cavity of a 12-Month-Old Female Donryu Rat
• The Kidneys of Infant Mice are not Sensitive to the Food Mycotoxin Contaminant Nivalenol
• Molecular mechanisms underlying ochratoxin A-induced genotoxicity : global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression

もっと見る 閉じる

スポンサーリンク