Chronic cadmium treatment induces islet B cell injury in ovariectomized cynomolgus monkeys
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概要
- 論文の詳細を見る
In an attempt to establish a primate model of chronic cadmium (Cd) toxicosis, we ovariectomized cynomolgus monkeys and treated with CdCl2 by repeated intravenous injections for 13 to 15 months. The animals showed an increase in blood glucose from Month 10 and a decrease in blood insulin at Month 11 of the Cd-treatment. Histopathological examination of the Cd-treated animals revealed islet atrophy with reduction in islet number and vacuolation of the islet cells, whereas there was no remarkable change in the acinar cells of the exocrine pancreas. In histomorphometrical examination, insulin-positive areas in the islets were significantly decreased, accompanying a relative increase of glucagon-positive areas. Large amounts of Cd accumulated in the pancreas, and metallothionein (MT), a Cd binding protein, was localized in the islets of Cd-treated animals. The present study demonstrated that the chronic intravenous injection of Cd to cynomolgus monkeys induced the accumulation of the metal in the pancreas, degeneration of islet B cells and the diabetic clinical signs. Therefore the islet B cell is one of the major targets of the chronic Cd poisoning in monkeys.
- 北海道大学の論文
- 2003-02-28
著者
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Umemura T
Division Of Pathology National Institute Of Health Sciences
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Doi Takuya
Kashima Laboratory, Mitsubishi Chemical Medience Corporation
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UMEMURA Takashi
Laboratory of Comparative Pathology, Hokkaido University School of Veterinary Medicine
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TSUCHITANI Minoru
Mitsubishi Chemical Safety Institute Ltd.
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Hiratsuka Hideaki
Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd.
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Tsuchitani Minoru
Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd.
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Hiratsuka Hideaki
Kashima Laboratory Mitsubishi Chemical Safety Institute Ltd.
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Hiratsuka Hideaki
Kashima Laboratory Of Mitsubishi Chemical Safety Institute Ltd.
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Unno Takashi
Division Of Pathology National Institute Of Health Sciences
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Umemura T
Hokkaido Univ. Sapporo Jpn
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Umemura Takashi
Laboratory Of Comparative Pathology Department Of Veterinary Clinical Sciences Graduate School Of Ve
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Doi Takuya
Kashima Laboratory Mitsubishi Chemical Medience Corporation
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Unno Takashi
Japan Pharmaceutical Manufactures Association (jpma):kanebo Ltd
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DOI Takuya
Mitsubishi Chemical Safety Institute Ltd.
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Tsuchitani M
Mitsubishi Chemical Safety Institute Ltd.
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Tuchitani Minoru
Mitsubishi Chemical Safety Institute Ltd.
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TAKAHASHI Kaname
Mitsubishi Chemical Safety Institute Ltd.
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KATSUTA Osamu
Mitsubishi Chemical Safety Institute Ltd.
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Kurata Yoshimasa
Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of
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Katsuta Osamu
Kashima Laboratory of Mitsubishi Chemical Safety Institute Ltd.
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Kawasuso Takeshi
Kashima Laboratory of Mitsubishi Chemical Safety Institute Ltd.
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Katsuta O
Mitsubishi Chemical Safety Institute Ltd.
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Katsuta Osamu
Kashima Laboratory Mitsubishi Chemical Safety Institute Ltd.
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Kurata Yoshimasa
Laboratory Of Comparative Pathology Department Of Veterinary Clinical Sciences Graduate School Of Ve
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Tsuchitani Minoru
Kashima Laboratory Mitsubishi Chemical Safety Institute Ltd.
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Umemura Takashi
Laboratory Of Comparative Pathology Graduate School Of Veterinary Medicine Hokkaido University
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Tsuchitani Minoru
Kashima Laboratory Mitsubishi Chemical Safery Institute Ltd.
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Kanno Takeshi
Kashima Laboratory, Mitsubishi Chemical Medience Corporation
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