Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
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概要
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Carcinosarcomas are rare tumors in humans as well as rats and most commonly occur in the uterus. Recently, we observed a case of incidental carcinosarcoma of the uterus in a female Wistar Hannover GALAS [BrlHan:WIST@Jcl (GALAS)] rat at 2 years of age. Histopathologically, the tumor was characterized by an admixture of malignant epithelial and nonepithelial elements. The carcinomatous components represented a type of endometrial carcinoma, consisting of glandular and solid proliferation of large-sized tumor cells. Prominent mitoses and tumor cell invasion were observed. The sarcomatous components were characterized by multifocal proliferation of severe atypical cells with cartilage matrix and were diagnosed as chondrosarcoma. Transitions between carcinomatous and sarcomatous components were observed, and many tumor cells in the solid lesion showed immunohistochemical reactivity with both cytokeratin and vimentin. Based on these findings, this tumor was diagnosed as a uterine carcinosarcoma. This is the first report of uterine carcinosarcoma in Wistar Hannover GALAS [BrlHan:WIST@Jcl (GALAS)] rats.
著者
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Umemura T
Division Of Pathology National Institute Of Health Sciences
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Takami Shigeaki
Division of Pathology, National Institute of Health Sciences
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Cho Young-Man
Division of Pathology, National Institute of Health Sciences
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Nishikawa Akiyoshi
Division of Pathology, National Institute of Health Sciences
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OKAMURA Toshiya
Division of Pathology, National Institute of Health Sciences
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ISHII Yuji
Division of Pathology, National Institute of Health Sciences
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UMEMURA Takashi
Division of Pathology, National Institute of Health Sciences
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TASAKI Masako
Division of Pathology, National Institute of Health Sciences
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Tasaki Masako
Division Of Pathology National Institute Of Health Sciences
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Inoue Tomoki
Division of Pathology, National Institute of Health Sciences
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Okamura Toshiya
Division Of Pathology National Institute Of Health Sciences
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Cho Young-man
Division Of Pathology National Institute Of Health Sciences
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Suzuki Yuta
Division of Cardiology Department of Medicine, Keio University School of Medicine
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Jin Meilan
Division Pathology, Biological Safety Research Center, National Institute of Health Sciences
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Ishii Yuji
Division Of Pathology National Institute Of Health Sciences
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Inoue Tomoki
Division Of Pathology National Institute Of Health Sciences
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Nishikawa Akiyoshi
Division Of Pathology Biology Safety Research Center National Institute Of Health Sciences
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Suzuki Yuta
Division Of Cardiology Department Of Medicine Keio University School Of Medicine
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Umemura Takashi
Division Of Pathology National Institute Of Health Sciences
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Unno Takashi
Division Of Pathology National Institute Of Health Sciences
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Umemura Takashi
Division Of Pathology National Institute Of Health Science
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Unno Takashi
Japan Pharmaceutical Manufactures Association (jpma):kanebo Ltd
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Takami Shigeaki
Division Of Pathology National Institute Of Health Sciences
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Ogawa Kumiko
Division of Pathology, National Institute of Health Sciences
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Hibi Daisuke
Division of Pathology, National Institute of Health Sciences
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Hibi Daisuke
Division Of Pathology National Institute Of Health Sciences
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Umemura Takashi
Laboratory Of Comparative Pathology Graduate School Of Veterinary Medicine Hokkaido University
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Ishii Yuji
Division Of Pathology National Institute Of Health Science
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Jin Meilan
Division Of Pathology National Institute Of Health Sciences
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Ogawa Kumiko
Division Of Pathology National Institute Of Health Sciences
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