In vitro demonstration of neural transmission of avian influenza A virus

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概要

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• Neural involvement following infections of influenza viruses can be serious. The neural transport of influenza viruses from the periphery to the central nervous system has been indicated by using mouse models. However, no direct evidence for neuronal infection has been obtained in vitro and the mechanisms of neural transmission of influenza viruses have not been reported. In this study, the transneural transmission of a neurotropic influenza A virus was examined using compartmentalized cultures of neurons from mouse dorsal root ganglia, and the results were compared with those obtained using the pseudorabies virus, a virus with well-established neurotransmission. Both viruses reached the cell bodies of the neurons via the axons. This is the first report on axonal transport of influenza A virus in vitro. In addition, the role of the cytoskeleton (microtubules, microfilaments and intermediate filaments) in the neural transmission of influenza virus was investigated by conducting cytoskeletal perturbation experiments. The results indicated that the transport of avian influenza A virus in the neurons was independent of microtubule integrity but was dependent on the integrity of intermediate filaments, whereas pseudorabies virus needed both for neural spread.

• Society for General Microbiologyの論文

著者

• 落合 謙爾

  北海道大学大学院獣医学研究科比較病理学研究室

• Umemura T

  Division Of Pathology National Institute Of Health Sciences

• 落合 謙爾

  北海道大学大学院獣医学研究科比較病理学教室

• Oguma Keiji

  Department Of Bacteriology Okayama University Medical School.

• Ochiai Kenji

  Hokkaido Univ. Sapporo Jpn

• Ochiai Kenji

  Department Of Applied Chemistry Graduate School Of Engineering Nagoya University:(present Address)ba

• Ochiai Kenji

  Laboratory Of Comparative Pathology Graduate School Of Veterinary Medicine Hokkaido University

• Ochiai Kenji

  Laboratory Of Comparative Pathology Department Of Veterimary Sciences Graduate School Of Veterimary

• Ochiai Kenji

  Department Of Comparative Pathology Faculty Of Veterinary Medicine Hokkaido University

• Sakoda Yoshihiro

  Hokkaido Univ. Sapporo Jpn

• Umemura Takashi

  Division Of Pathology National Institute Of Health Sciences

• Unno Takashi

  Division Of Pathology National Institute Of Health Sciences

• Umemura T

  Hokkaido Univ. Sapporo Jpn

• Unno Takashi

  Japan Pharmaceutical Manufactures Association (jpma):kanebo Ltd

• Kida Hiroshi

  北海道大学大学院獣医学研究科微生物学教室

• Kimura T

  Laboratory Of Comparative Pathology Graduate School Of Veterinary Medicine Hokkaido University

• Kida Hiroshi

  Hokkaido Univ. Sapporo Jpn

• Umemura Takashi

  Laboratory Of Comparative Pathology Graduate School Of Veterinary Medicine Hokkaido University

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