Oxidative DNA damage and reporter gene mutation in the livers of gpt delta rats given non-genotoxic hepatocarcinogens with cytochrome P450-inducible potency
スポンサーリンク
概要
- 論文の詳細を見る
- 2010-12-10
著者
-
Umemura T
Division Of Pathology National Institute Of Health Sciences
-
ISHII Yuji
Division of Pathology, National Institute of Health Sciences
-
Nishimura T
Division Of Environmental Chemistry
-
Tasaki Masako
Division Of Pathology National Institute Of Health Sciences
-
Inoue Tomoki
Division of Pathology, National Institute of Health Sciences
-
Okamura Toshiya
Division Of Pathology National Institute Of Health Sciences
-
Ishii Yuji
Division Of Pathology National Institute Of Health Sciences
-
Suzuki Yuta
Division Of Pathology National Institute Of Health Sciences
-
Inoue Tomoki
Division Of Pathology National Institute Of Health Sciences
-
Nishikawa A
Div. Of Pathology National Inst. Of Health Sciences
-
Nishikawa Akiyoshi
Division Of Pathology Biology Safety Research Center National Institute Of Health Sciences
-
Nishikawa A
National Inst. Health Sci. Tokyo Jpn
-
Nishikawa A
National Institute Of Health Science Osaka Branch National Institute Of Health Sciences
-
Suzuki Yuta
Division Of Cardiology Department Of Medicine Keio University School Of Medicine
-
Umemura Takashi
Division Of Pathology National Institute Of Health Sciences
-
Maruyama Soichi
Laboratories Of Veterinary Public Health Department Of Veterinary Medicine College Of Bioresource Sc
-
Unno Takashi
Division Of Pathology National Institute Of Health Sciences
-
Umemura T
Hokkaido Univ. Sapporo Jpn
-
Umemura Takashi
Division Of Pathology National Institute Of Health Science
-
Maruyama Satoshi
Department Of Analytical Chemistry Hoshi University
-
Unno Takashi
Japan Pharmaceutical Manufactures Association (jpma):kanebo Ltd
-
Nohmi Takehiko
Division Of Genetics And Mutagenesis National Institute Of Health Sciences
-
Hibi Daisuke
Division of Pathology, National Institute of Health Sciences
-
Masegi Toshiaki
Department Of Veterinary Pathology Faculty Of Agriculture Gifu University
-
Hibi Daisuke
Division Of Pathology National Institute Of Health Sciences
-
Maruyama Soichi
Laboratory Of Veterinary Public Health Department Of Veterinary Medicine College Of Bioresource Scie
-
Umemura Takashi
Laboratory Of Comparative Pathology Graduate School Of Veterinary Medicine Hokkaido University
-
Nishikawa Akiyoshi
Division Of Pathology Nihs
-
Ishii Yuji
Division Of Pathology National Institute Of Health Science
関連論文
- A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats
- Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide
- Lack of modifying effects of prepubertal exposure to acrylamide (AA) on N-methyl-N-nitrosourea (MNU)-induced multi-organ carcinogenesis in F344 rats
- Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
- Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
- Rapid Screening for Chemopreventive Agents in Herbal Extracts in a PhIP Rat Model with DNA Adduct and Cell Proliferation as End-Points
- DNA Adduct Formation, Nucleolar Segregation and Cell Proliferation in Rats Treated with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
- In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- In vivo mutagenicity and oxidative DNA damage in the livers of gpt delta mice treated with flumequine(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Catechol enhanced mice hepatotoxicity treated with acetaminophen(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- Lack of Initiating Activity of Kojic Acid on Hepatocarcinogenesis in F344 Rats
- Electron Microscopical Evidence of the Protective Function of Thioredoxin (TRX/ADF) Transgene against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced Cellular Toxicity in the Liver and Brain
- P8-27 Susceptibility to pentachlorophenol, a mouse liver carcinogen in Nrf2-deficient mice(CIRCULATORY SYSTEM-2/ACTIVE OXYGEN)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- P6-43 Screening of chemopreventive agents using a medium-term pancreas carcinogenesis model in hamsters(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Dose-related changes of oxidative stress and cell proliferation in kidneys of male and female F344 rats exposed to potassium bromate
- Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl) nitrosamine in rats after initiation
- A possible role of oxidative stress in potassium bromate (KBrO_3) carcinogenesis (ACTIVE OXYGEN) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl) nitrosamine
- Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis : Results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- In vivo Approaches to Study Mechanism of Action of Genotoxic Carcinogens
- Mechanistic study on hepatocarcinogenesis induced by dicyclanil in mice : possible involvement of oxidative stress(Proceedings of the 32nd Annual Meeting)
- The Mouse rasH2/BHT Model as an in vivo Rapid Assay for Lung Carcinogens
- Enhancement by Cigarette Smoke Exposure of 2-Amino-3,8-dimethylimidazo [4,5-f] quinoxaline-induced Rat Hepatocarcinogenesis in Close Association with Elevation of Hepatic CYP1A2
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- Prevention by 2-Mercaptoethane Sulfonate and N-Acetylcysteine of Renal Oxidative Damage in Rats Treated with Ferric Nitrilotriacetate
- 3A-08 A Chronic Inhalation Study of p-Dichlorobenzene in the F344 Rat
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- A SURVEY OF THE VALUES OF CLINICAL CHEMISTRY PARAMETERS OBTAINED FOR A COMMON RAT BLOOD SAMPLE IN NINETY-EIGHT JAPANESE LABORATORIES
- Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
- Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice
- Involvement of Lipid Peroxidation in Spontaneous Pancreatitis in WBN/Kob Rats
- Morphological characterization of the ovary under normal cycling in rats and its viewpoints of ovarian toxicity detection
- Renal Carcinogenicity of Concurrently Administered Fish Meal and Sodium Nitrite in F344 Rats
- Inhibition by β-Carotene of Upper Respiratory Tumorigenesis in Hamsters Receiving Diethylnitrosamine Followed by Cigarette Smoke Exposure
- Enhancing Effects of Quinacrine on Development of Hepatopancreatic Lesions in N-Nitrosobis (2-oxopropyl) amine-initiated Hamsters
- Mechanistic Insights into Chemopreventive Effects of Phenethyl Isothiocyanate in N-Nitrosobis (2-oxopropyl) amine-treated Hamsters
- "P-34 Inhibitory Effects of 2-Mercaptoethane Sulfonate on the Development of Cholangiofibrosis in Rats induced by N-Nitrosopyrrolldine.
- "P-26 Long-term Effects of Cortisol Acetate on Rat Pancreas.
- "P-22 A Combination Toxicity Study of Sodium Ascorbate and Sodium Nitrite In Rats
- Chemopreventive Effects of 3-Phenylpropyl Isothiocyanate on Hamster Lung Tumorigenesis Initiated with N-Nitrosobis (2-oxopropyl) amine
- Synergistic Effects of High-dose Soybean Intake with Iodine Deficiency, but Not Sulfadimethoxine or Phenobarbital, on Rat Thyroid Proliferation
- Lack of Effect of Soy Isoflavone On Thyroid Hyperplasia in Rats Receiving an Iodine-deficient Diet
- P-14 Effects of antioxidants on spontaneous hepatic and renal lesions in LEC rats.(Proceedings of the 27th Annual Meeting)
- Lack of Modification by Environmental Estrogenic Compounds of Thyroid Carcinogenesis in Ovariectomized Rats Pretreated with N-bis(2-hydroxynronyl)nitrosamine (DHPN)
- Lack of Modifying Effects of Environmental Estrogenic Compounds on the Development of Thyroid Proliferative Lesions in Male Rats Pretreated with N-Bis(2-hydroxypropyl)nitrosamine(DHPN)
- Inhibitory Effects of 1'-Acetoxychavicol Acetate on N-Nitrosobis(2-oxopropyl)-amine-induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters
- REVISION AND ESTABLISHMENT OF JAPANESE DRINKING WATER QUALITY GUIDELINES FOR DI(2-ETHYLHEXYL) PHTHALATE, TOLUENE AND VINYL CHLORIDE : DIFFERENCES FROM THE LATEST WHO GUIDELINE DRAFTS
- Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model
- Long-Term Treatment with Bromocriptine Inhibits Endometrial Adenocarcinoma Development in Rats
- Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods-a preliminary study
- TOXICITY STUDY OF A RUBBER ANTIOXIDANT, 2-MERCAPTOBENZIMIDAZOLE, BY REPEATED ORAL ADMINISTRATION TO RATS
- A 13-WEEK TOXICITY STUDY OF SIMULTANEOUS ADMINISTRATION OF COCHINEAL AND ALUMINUM POTASSIUM SULFATE IN RATS
- Impaired Myelinogenesis and Early Maturation of Oligodendrocytes in Black Tremor Hamster with Central Nervous System Myelin Deficiency
- Sustained hypomyelination and high serum thyroid hormone in aged black tremor hamster
- "P-12 The effects of 90-day feeding of Aramite or other herbicides of diphenyl ether group on livers, gall-bladders and bile ducts in dogs.
- Sample surveillance for clinical pathology testing.
- B-22 A 28-DAY REPEATED DOSE TOXICITY TEST AND THE TIME COURSE OF CHOLINESTERASE ACTIVITY TEST FOR CHLORPYRIFOS IN WISTAR RAT
- B38 COMPARISON OF TOXICITY OF p-DCB IN MALE AND FEMALE RATS
- "P-35 Contribution of Oxidative Stress to Rat Hepatotoxicity induced by 2-Nitropropane : Lipid Peroxidation and Inhibitory Effect of Green Tea.
- COMRARISON OF TOXICITY OF p-DICHLOROBENZENE (p-DCB) GIVEN ORALLY AND BY INHALATION
- O-55 HEMATOTOXICICOLOGIC CHARACTERISTICS FOR OXIDATIVE STRESSES INTRANSGENIC AND/OR KNOCK-OUT MICE FOR THIOREDOXIN/ADF GENE.(Proceedings of the 27th Annual Meeting)
- 21B-10-4 Benzene hemopoietic toxicity revisited- a new concept.
- 3A-09 Hemopoietic Stem-Cell Kinetics Evaluated by Bromodeoxyuridine Incorporation Followed by Near-UV Exposure to Kill Cycling Stem Cells (BUUV). 2) Bone Marrow Cells from Mice Carrying Human c-myc Proto-Oncogene with Promoters Combined with Immunoglobuli
- "P-8 Experimental myelodysplasia induced by Azidothymidine (AZT) : Hemopoietic Stem Cell Kinetics And Pathological Findings.
- Sample surveillance for clinical pathology testing(2) Analysis of blood chemical data
- 28-DAY REPEATED-DOSE ORAL TOXICITY STUDY OF 2-MERCAPTOBENZIMIDAZOLE, A RUBBER ANTIOXIDANT, IN RATS
- A 14-WEEK ORAL TOXICITY STUDY OF TRIBUTOXYETHYL PHOSPHATE(TBEP) IN RATS
- Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
- "B-3 Toxicokinetic Study of 2-Mercaptobenzimidazole (MBI) and its Methylated Derivative (MMBI) in Rats after Single Oral-Dose Administration.
- Inhibitory effects of aminoguanidine on thyroid follicular carcinoma development in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation
- 22D-11-3 Increased Liver and Kidney Toxicities in Rats Caused by Co-administration of 2-Mercaptobenzimidazole (MBI) and Lipopolysaccharide (LPS) and Their Toxicokinetics (TK).
- Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassay
- Chronic cadmium treatment induces islet B cell injury in ovariectomized cynomolgus monkeys
- P10-16 Increased osteoid volume and iron deposition of the Iumbar vertebra in a chronic cadmium toxicosis model of cynomolgus monkeys.
- 21D-04-1 Quantitative Analysis of Bone Lesion in Ovariectomized Cynomolgus Monkeys Given Repeated Intravenous Injections of CdCl_2.
- Comparison of Antibody Titers in Rabbits Following Immunization with Inactivated Influenza Virus via Subarachnoidal or Subcutaneous Route
- Efficacy of Intracerebral Immunization against Pseudorabies Virus in Mice
- In vitro demonstration of neural transmission of avian influenza A virus
- Laboratory of Comparative Pathology
- The Effects of a Vitamin D-deficient Diet on Chronic Cadmium Exposure in Rats
- ACUTE TOXICITY OF CADMIUM IN RATS WITH OR WITHOUT CADMIUM PRETREATMENT
- 302 EFFECTS OF CADMIUM CHLORIDB ON THE BLOOD AND URINARY EXAMINATIONS IN OVARIECTOMIZED RATS
- Oxidative DNA damage and reporter gene mutation in the livers of gpt delta rats given non-genotoxic hepatocarcinogens with cytochrome P450-inducible potency
- Lack of chronic toxicity and carcinogenicity of dietary administrated catechin mixture in Wistar Hannover GALAS rats
- Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats
- Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats
- Estrogen and androgen receptor status in hepatocellular hypertrophy induced by phenobarbital, clofibrate, and piperonyl butoxide in F344 rats
- Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action
- Toxic effects of a horseradish extract and allyl isothiocyanate in the urinary bladder after 13-week administration in drinking water to F344 rats
- Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats
- In vivo genotoxicity of 1-methylnaphthalene from comprehensive toxicity studies with B6C3F1 gpt delta mice
- Female heterozygous (+/fa) Zucker rats as a novel leptin-related mammary carcinogenesis model
- Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
- Reporter gene mutation in the livers of gpt delta mice treated with 5-(hydroxymethyl)-2-furfural, a contaminant of various foods
- Undifferentiated Sarcoma of the Salivary Gland in a Mongolian Gerbil (Meriones unguiculatus)
- Rhabdomyosarcoma in the Abdominal Cavity of a 12-Month-Old Female Donryu Rat