Effects of repeated administrations of facteur thymique serique(FTS) on biochemical changes related to aging in senescence-accelerated mouse(SAM).
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概要
- 論文の詳細を見る
Superoxide dismutase (SOD) activity, malondialdehyde (MDA) content and monoamine oxidase B (MAO-B) activity were measured in the brain, liver and kidney of a normal aging strain (R/1) and an accelerating aging strain (P/8) senescence-accelerated mice (SAM) at 9-10 months of age, and the effects of facteur thymique sérique (FTS) were examined. The activity of Cu, Zn-SOD in the kidney and MAO-B in the liver was significantly low and high in SAM-P/8 compared to SAM-R/1. FTS enhanced the activity of Mn-SOD and Cu, Zn-SOD in the kidney of SAM-P/8 and Cu, Zn-SOD activity in the brain of both SAM-P/8 and SAM-R/1. It decreased the activity of MAO-B in the liver and the contents of malondialdehyde (MDA) in the brain and kidney of SAM-P/8. Thus, FTS affects the biochemical factors related to senescence in SAM-P/8, a particular senescent animal model, and may thus possibly be effective as an anti-senescent medicine.
- 公益社団法人 日本薬理学会の論文
著者
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NOMURA Yasuyuki
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Awaya Akira
Institute Of Biological Science Mitsui Pharmaceuticals Inc.
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Ohnuki Toshio
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
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Tokumitsu Yukiko
Department Of Ph Ysiological Chemistry Faculty Of Pharmaceutical Sciences Hokkaido University
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Nomura Yasuyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University
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ZHAO Xue-Hui
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University
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KOBAYASHI Hisashi
Institute of Biological Sciences, Mitsui Pharmaceuticals, Inc.
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