Neurotropic Pyrimidine Heterocyclic Compounds. II. Effects of Novel Neurotropic Pyrimidine Derivatives on Astrocytic Morphological Differentiation
スポンサーリンク
概要
- 論文の詳細を見る
Astrocytes play an important role in supporting nerve regeneration after brain injuries. In this study, the effects of novel neurotropic synthesized pyrimidine compounds on astrocytic morphological differentiation were examined. Treatment of protoplasmic cultured astrocytes with 2-piperidino-5,6-dihydro-7-methyl-6-oxo(7H)pyrrolo[2,3-d]pyrimidine maleate (MS-430) and the related compounds caused astrocytic process formation in 60 min. The morphology of MS-430-treated cells was similar to that of dibutyryl cAMP (DBcAMP)-treated cells. The astrocytic process formation by MS-430 was observed within 60 min and the maximum effect was obtained at the drug concentration of 0.5-1.0 mM. Rhodamine-phalloidin staining showed that astrocytic cytoskeletal actin was reorganized by MS-430 and DBcAMP. MS-430 did not increase cAMP accumulation in cultured astrocytes. These results suggest that the neurotropic pyrimidines induced astrocytic morphological differentiation through a cAMP-independent mechanism.
- 公益社団法人日本薬学会の論文
- 1997-02-15
著者
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AWAYA Akira
Institute of Biological Science, Mitsui Pharmaceuticals Inc., 3-12-2, Nihonbashi, Chuo-ku, Tokyo 103
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KOYAMA Yutaka
Department of Chemical Engineering, Faculty of Engineering, Iwate University
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BABA Akemichi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
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Koyama Yutaka
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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FUJITA Shigeki
Department of Pathology, Osaka Police Hospital
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Baba Akemichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
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ISHIKAWA Nobue
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
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TOMINO Ikuo
Synthetic Chemistry and Bioscience Lab., Mitsui Petrochemical Industries, Ltd.
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YOKOYAMA Keiichi
Synthetic Chemistry and Bioscience Lab., Mitsui Petrochemical Industries, Ltd.
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ARAKI Shintaro
Synthetic Chemistry and Bioscience Lab., Mitsui Petrochemical Industries, Ltd.
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TAKESUE Mitsuyuki
Synthetic Chemistry and Bioscience Lab., Mitsui Petrochemical Industries, Ltd.
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KATO Koji
Synthetic Chemistry and Bioscience Lab., Mitsui Petrochemical Industries, Ltd.
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ISHIGURO Masaharu
Synthetic Chemistry and Bioscience Lab., Mitsui Petrochemical Industries, Ltd.
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KITAHARA Takumi
Synthetic Chemistry and Bioscience Lab., Mitsui Petrochemical Industries, Ltd.
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KIHARA Noriaki
Synthetic Chemistry and Bioscience Lab., Mitsui Petrochemical Industries, Ltd.
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横山 恵一
Synthetic Chemistry & Bioscience Laboratories Mitsui Petrochemical Industries Ltd.
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Koyama Yutaka
Department Of Cardiology
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Tomino Ikuo
Synthetic Chemistry And Bioscience Lab. Mitsui Petrochemical Industries Ltd.
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Awaya Akira
Institute Of Biological Science Mitsui Pharmaceuticals Inc.
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Kihara Noriaki
Synthetic Chemistry And Bioscience Lab. Mitsui Petrochemical Industries Ltd.
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Araki S
Eisai Co. Ltd. Ibaraki Jpn
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Fujita Shigeki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
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Fujita Shigeki
Department Of Pathology Osaka Police Hospital
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Ishikawa Nobue
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
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Kitahara Takumi
Synthetic Chemistry And Bioscience Lab. Mitsui Petrochemical Industries Ltd.
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Yamanouchi K
Synthetic Chemistry And Bioscience Lab. Mitsui Petrochemical Industries Ltd.
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Araki Shintaro
Synthetic Chemistry And Bioscience Lab. Mitsui Petrochemical Industries Ltd.
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Takesue Mitsuyuki
Synthetic Chemistry And Bioscience Lab. Mitsui Petrochemical Industries Ltd.
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Ishiguro Masaharu
Synthetic Chemistry And Bioscience Lab. Mitsui Petrochemical Industries Ltd.
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Kato Koji
Synthetic Chemistry And Bioscience Lab. Mitsui Petrochemical Industries Ltd.
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