Effect of Dibutyryl Cyclic AMP-Treatment on Prostaglandin F2.ALPHA.-Stimulated Phosphoinositide Hydrolysis in Cultured Rat Astrocytes.
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概要
- 論文の詳細を見る
Dibutyryl cyclic AMP (dBcAMP)-treatment of cultured rat astrocytes induced changes in astrocyte morphology followed by the potentiation of prostaglandin F<SUB>2α</SUB> (PGF<SUB>2α</SUB>)-stimulated phosphoinositide (PI) hydrolysis. The potentiation was observed in astrocytes of the cerebral cortex, cerebellum, and hippocampus. The dBcAMP-treatment induced agonists-specific changes in PI hydrolysis; e.g., the potentiation of norepinephrine-effect and the reduction of the carbachol-effect. Coincubations of carbachol or norepinephrine with PGF<SUB>2α</SUB> produced additive responses.
- 公益社団法人 日本薬理学会の論文
著者
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Baba Akemichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
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KITANAKA Jun-ichi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
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