NMDA Induces Protein Kinase C Translocation in Guinea Pig Cerebral Synaptoneurosomes.
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概要
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N-methyl-D-aspartate (NMDA)-induced translocation of protein kinase C from the cytosol to membrane fractions was examined by the [<SUP>3</SUP>H]phorbol 12, 13-dibutyrate (PDBu) binding method in guinea pig cerebral synaptoneurosomes. Pretreatment of synaptoneurosomes with NMDA, but not that with quisqualate or kainate, induced changes in the distribution of [<SUP>3</SUP>H]PDBu binding in the cytosol and membrane fractions in a dose-dependent manner. The NMDA-induced changes of the binding were completely dependent on Ca<SUP>2+</SUP> and inhibited by NMDA receptor antagonists Mg<SUP>2+</SUP>, 2-amino-5-phosphonovaleric acid and ketamine, but not by Zn<SUP>2+</SUP>. Glycine slightly potentiated the NMDA-induced changes of [<SUP>3</SUP>H]PDBu binding. NMDA stimulated Ca<SUP>2+</SUP> uptake but not the phosphoinositide hydrolysis in the synaptoneurosomes. These results suggest that NMDA enhances Ca<SUP>2+</SUP> influx through receptor-operated Ca<SUP>2+</SUP> channels, increasing intracellular calcium concentration and thereby induces translocation of protein kinase C.
- 公益社団法人 日本薬理学会の論文
著者
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Baba Akemichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
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Iwata Heitaroh
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
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Etoh Susumu
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
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