EFFECTS OF ACUTE AND CHRONIC MORPHINE TOLERANCE ON THE SERUM COPPER, CERULOPLASMIN AND HEPATIC COPPER CONTENTS
スポンサーリンク
概要
- 論文の詳細を見る
Former papers from this laboratory reported that on treatment with sodium diethyldithiocarbamate (DDC), a dopamine-β-hydroxylase inhibitor and a chelating agent for copper, the analgesic action of morphine was potentiated in rats (1, 2). Although the possibility that effect of DDC on morphine analgesia might be related to catecholamine metabolism cannot be completely excluded, we clarified that the changes in copper metabolism of the blood and tissues in rats could be responsible for the potentiation of morphine analgesia by DDC and that fluctuation of the copper metabolism in rats by the treatment of morphine may be involved in the manifestation of analgesia and development of tolerance to the analgesia (2, 3).<BR> Some authors have postulated that the development of acute and chronic tolerance to the analgesic action of morphine in rats appears to involve RNA and/or protein synthesis (4-6), because tolerance is prevented by drugs which inhibit RNA or protein synthesis.<BR> The increase in the ceruloplasmin content in the serum, due to its synthesis in the liver after injection of copper, was also inhibited by actinomycin D and cycloheximide (7). Since the plasma copper content increases in animals which are tolerant to morphine analgesia (2), it seemed interesting to examine the effects of repeated intravenous injections or chronic treatment with morphine on the content of the serum copper protein, ceruloplasmin, during development of tolerance to the analgesic action of morphine. The present paper reports changes in the levels of serum copper, ceruloplasmin, hepatic copper and biliary excretion of copper in rat tolerated to the analgesic action of morphine caused by repeated intravenous or by chronic subcutaneous injections of morphine (acute or chronic morphine tolerant rat, respectively).
- 社団法人 日本薬理学会の論文
著者
-
Iwata Heitaroh
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
-
WATANABE Kouichi
Reproduction Research Branch, National Institute of Child Health and Human Development, National Ins
-
WATANABE Kouichi
Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health
-
IWATA Heitaroh
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University,
関連論文
- INHIBITION OF [^3H] GLUTAMATE RELEASE BY ZN^ IN RAT HIPPOCAMPAL SLICES
- Effect of Diphenylthiocarbazone (Dithizone) on Glutamate Level in Hippocampus Preparation in Vitro and in Vivo
- REGULATION BY GONADAL HORMONES OF 5-HT_ RECEPTOR-MEDIATED ACTIVATION OF HYPOTHALAMUS-PITUITARY-ADRENOCORTICAL AXIS
- AGONIST ACTIVITY OF A NOVEL COMPOUND, BP-554,AT CENTRAL SEROTONIN-1A RECEPTORS
- THE ACTIONS OF SODIUM NITROPRUSSIDE AND DILTIAZEM ON CALCIUM-, POTASSIUM- AND HISTAMINE-INDUCED CONTRACTILE RESPONSES IN ISOLATED RABBIT BASILAR ARTERY, AORTA, TAENIA COLI AND TRACHEAL SMOOTH MUSCLE
- INFLUENCE OF DIETHYLMALEATE ON THE FORMATION OF BIS(METHYLMERCURIC)SELENIDE AND METHYLMERCURY DISTRIBUTION IN RATS
- 112. EFFECT OF SELENIUM ON THE TOXICITY OF CADMIUM : REPORT 2 (The Second Meeting for the Study of Toxic Effect)
- ACTIVATION OF ALLOPURINOL OXIDIZING ENZYME ACTIVITY OF THE DIALYSATE OF MOUSE LIVER SUPERNATANT BY MONOVALENT CATIONS
- TISSUE DISTRIBUTION AND CHARACTERISTICS OF XANTHINE OXIDASE AND ALLOPURINOL OXIDIZING ENZYME
- BIOLOGICAL INTERACTION OF SELENIUM WITH METHYLMERCURY
- SELENITE-INDUCED CHANGE OF METHYLMERCURY DISTRIBUTION IN RATS
- MECHANISM OF ACCUMULATION OF TAURINE IN THE HEART OF STARVED RATS
- INCREASE OF BRAIN TAURINE CONTENTS OF EL MICE BY PHYSIOLOGICAL STIMULATION
- EFFECTS OF ACUTE AND CHRONIC MORPHINE TOLERANCE ON THE SERUM COPPER, CERULOPLASMIN AND HEPATIC COPPER CONTENTS
- EFFECT OF CHRONIC ADMINISTRATION OF BARBITAL SODIUM ON CALCIUM CONTENT IN RAT BRAIN TISSUE
- INFLUENCE OF DIETARY SELENIUM ON GLUTATHIONE S-TRANSFERASE ACTIVITY AND PROSTAGLANDIN BIOSYNTHESIS IN RAT VARIOUS TISSUES
- STUDIES ON THE CANCEROSTATIC ACTIVITY OF MERBROMIN
- 231. SELENIUM METABOLISM IN RAT ERYTHROCYTES (The Third Meeting for the Study of Toxic Effect)
- SUPPRESSIVE ACTION OF SELENITE ON DRUG-INDUCED METHEMOGLOBINEMIA (The 6th Meeting for the Study of Toxic Effect)
- OCULAR ANTI-INFLAMMATORY AND SYSTEMIC IMMUNOSUPPRESSIVE EFFECTS OF TOPICALLY APPLIED FLUOROMETHOLONE
- EFFECTS OF VARIOUS DRUGS ON SERUM FREE AND TOTAL TRYPTOPHAN LEVELS AND BRAIN TRYPTOPHAN METABOLISM IN RATS
- ADRENERGIC MECHANISM IN TETRAHYMENA III CYCLIC ADENOSINE 3, 5-MONOPHOSPHATE AND CELL PROLIFERATION
- ROLE OF THIAMINE METABOLISM IN THE CENTRAL NERVOUS SYSTEM : I. BASIC PROPERTIES OF THIAMINE TRIPHOSPHATASE IN RAT BRAIN
- ADRENERGIC MECHANISM IN TETRAHYMENA II EFFECT OF ADRENALINE ON CELL PROLIFERATION
- CHANGE IN CATECHOLAMINE CONTENT OF TETRAHYMENA PYRIFORMIS W DURING GROWTH
- EFFECT OF LITHIUM ON SERUM TRYPTOPHAN AND BRAIN SEROTONIN IN RATS
- EFFECT OF TAURINE ON RESPONSES TO NORADRENALINE, ACETYLCHOLINE AND OUABAIN IN ISOLATED AURICLES FROM DIGITALIZED GUINEA PIGS
- Effect of 5-{3-(4-(4-fluorophenyl)-1-piperazinyl)-propoxy}indan(BP-528) on benzodiazepine receptor bindings and .GAMMA.-aminobutyric acid release.
- Stimulatory effect of veratridine on lysophosphatidylethanolamine formation in rat brain synaptosomes.
- PHARMACOLOGICAL STUDIES ON NITROGEN MUSTARD-N-OXIDES
- NMDA Induces Protein Kinase C Translocation in Guinea Pig Cerebral Synaptoneurosomes.
- Release of (3H).GAMMA.-aminobutyric acid by taurocyamine in rat brain slices.
- Taurine transport in chronically stimulated fast- and slow-twitch muscles of the rat.