EFFECTS OF VARIOUS DRUGS ON SERUM FREE AND TOTAL TRYPTOPHAN LEVELS AND BRAIN TRYPTOPHAN METABOLISM IN RATS
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概要
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Various drugs known to bind to serum albumin were examined to determine whether or not they influenced the level of free tryptophan in serum <I>in vitro</I> and <I>in vivo</I>. Possible relationships between the serum free tryptophan level and scrotonin (5-HT) synthesis in the brain and the hypothermic effects of these drugs were investigated. Of the drugs examined, sodium salicylate, sodium benzoate and indomethacin caused a significant increase in the concentration of serum free tryptophan and stimulated the synthesis of 5-HT in the brain. Hypothermia induced by salicylate and indomethacin was potentiated by pretreatment with pargyline, a monoamine oxidase inhibitor. Administration of benzoate did not cause any change in body temperature, but after pargyline a hypothermia did occur. However, pretreatment with parachlorophenylalanine, an inhibitor of 5-HT synthesis, did not influence the hypothermia induced by salicylate and indomethacin. Relationship between the hypothermic effect and the increase of 5-HT synthesis in the brain after a large dose of salicylate and indomethacin is discussed.
- 社団法人 日本薬理学会の論文
著者
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Iwata Heitaroh
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
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Okamoto Hiroshi
Department Of Advanced Biological Sciences For Regeneration (kotobiken Medical Laboratories) Tohoku
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KOH Setsuko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
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OKAMOTO Hiroshi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
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