EFFECT OF LITHIUM ON SERUM TRYPTOPHAN AND BRAIN SEROTONIN IN RATS
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概要
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The influence of lithium administration on brain serotonin metabolism and the serum tryptophan level in rats was investigated. The brain tryptophan, serotonin and 5-hydroxyindole acetic acid contents did not change after a single injection of lithium, but did increase significantly after repeated injections. A single injection of lithium caused a marked decrease in the serum total tryptophan level, but did not change the ratio of free to albumin bound tryptophan. On the contrary, repeated injections of lithium caused a significant increase in serum total tryptophan, and decrease in the ratio of free to bound tryptophan. Addition of lithium ion to normal rat serum <I>in vitro</I> did not change the ratio of free to bound tryptophan. A single injection of lithium produced a marked rise in serum nonesterified fatty acid, which is known to affect the binding of tryptophan by albumin.
- 公益社団法人 日本薬理学会の論文
著者
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Iwata Heitaroh
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
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Okamoto Hiroshi
Department Of Advanced Biological Sciences For Regeneration (kotobiken Medical Laboratories) Tohoku
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KURAMOTO Ikuko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
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