ADRENERGIC MECHANISM IN <I>TETRAHYMENA</I> III CYCLIC ADENOSINE 3, 5-MONOPHOSPHATE AND CELL PROLIFERATION
スポンサーリンク
概要
- 論文の詳細を見る
The presence of cyclic adenosine 3, 5-monophosphate (cAMP) in the ciliated protozoan, <I>Tetrahymena pyrifurmis</I> W, was demonstrated by thin-layer chromatography (TLC). The content of cAMP in the cell increased abruptly in the early exponential phase, and then diminished with further culture. When cells in the exponential or stationary growth phase were cultured in a fresh medium, growth was inhibited by addition of dibutyryl cAMP (Bt<SUB>2</SUB>-cAMP) or methylxanthines. In synchronized cultures of <I>Tetrahymena</I>, Bt<SUB>2</SUB>-cAMP inhibited protein and RNA syntheses in the G<SUB>1</SUB> phase and DNA synthesis in the S phase. These results indicate that cAMP regulates the growth of the protozoan in the G<SUB>1</SUB> phase.
- 社団法人 日本薬理学会の論文
著者
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IWATA Heitaroh
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
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Kariya Kimio
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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Iwata Heitaroh
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
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SAITO Katsuhisa
New Product Planning and Development Division, Pharmaceutical Affairs, Takeda Chemical Industries LT
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