CENTRAL ACTION OF BRADYKININ (I) ELECTROENCEPHALOGRAM OF BRADYKININ AND ITS DEGRADATION SYSTEM IN RAT BRAIN
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概要
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Both <I>in vivo</I> and <I>in vitro</I> experiments were performed to elucidate the relationship between the action of bradykinin (BK) and the possibility of release of pharmacologically active fragments from BK in the rat brain. In <I>in vivo</I> experiments, the activities of electroencephalogram (EEG) increased immediately after the intracerebral administration of 5 nmole BK. The effect was prolonged by intracerebral pretreatment of o-phenanthroline which inhibits plasma kininases. <I>In vitro</I> experiments, o-phenanthroline inhibited partially purified enzyme of rat brain which released fragments of BK possessing phenylalanine, serine, proline and/or arginine as N-terminal amino acids. Only arginine and minute amounts of phenylalanine were observed after the incubation with o-phenanthroline. The evidence suggests that the inhibition of the enzyme by o-phenanthroline resulted in a prolongation of the excited phase produced by BK on the EEG and on behavior. Supporting evidence indicates that Ser-Pro containing frag-ments derived from BK are concerned with the sedative phase of BK which was observed after the excitative stage.
- 社団法人 日本薬理学会の論文
著者
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Kariya Kimio
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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IWAKI Hideo
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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IHDA Mutsumi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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MARUTA Ehichi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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MURASE Makiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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