Relationship between hypertensive response and brain kinin level in the rat injected intraventricularly with glandular kallikrein.
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概要
- 論文の詳細を見る
Hypertens1ve action was observed in conscious rats injected intraventricularly with glandular kallikrein (EC 3.4.21.35) in a dose-dependent manner (4-16 KU), which was associated with the enhancement of brain kinin level. Concurrently administered aprotinin, a kallikrein inhibitor, led to an inhibition of these effects of kallikrein. These results suggest that the central hypertensive action of kallikrein is mediated via the kinin liberated from a kininogen in the brain.
- 公益社団法人 日本薬理学会の論文
著者
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Yamauchi Aiko
Department Of Pharmaceutical Information Science Graduate School Of Pharmaceutical Sciences Universi
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Kariya Kimio
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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