Major Role of Soybean Oil in Preventing Decrease in CYP4A1 mRNA Content Relative to PPARα mRNA Down-Regulation in Infant Rats(Pharmacology)
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概要
- 論文の詳細を見る
Changes in the levels of CYP4A1, PPARα, and RXRα mRNA expression in the liver following overdose of fat-free or fat-containing total parenteral nutrition (TPN) were studied in 3-week-old male Sprague-Dawley rats. The rats were divided into three groups: group 1, oral diet; group 2, fat-free TPN; and group 3, TPN with 20% of calories from soybean oil emulsion. Levels of CYP4A1, PPARα, and RXRα mRNA in the fat-free TPN group were significantly lower than those in the other groups. Levels of CYP4A1 and PPARα mRNA were strongly correlated (r=0.849), and levels of CYP4A1 and RXRα mRNA were weakly correlated (r=0.618). This is the first report of a strong correlation between the levels of CYP4A1 and PPARα mRNA following overdose of fat-free or fat-containing TPN in infant rats. Our results also indicate that it is important to include fat in TPN regimens in order to prevent CYP4A1 mRNA down-regulation, which may be related to changes in PPARα mRNA levels in the liver.
- 公益社団法人日本薬学会の論文
- 2005-08-01
著者
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山内 あい子
徳島大学薬学部
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YAMAUCHI Aiko
Department of Pharmaceutical Information Science, Graduate School of Pharmaceutical Sciences, Univer
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KISHIMOTO Sanae
Research and Development Center, Otsuka Pharmaceutical Factory, Inc.
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NAITO Shinsaku
Research and Development Center, Otsuka Pharmaceutical Factory, Inc.
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Nishimura M
Research And Development Center Otsuka Pharmaceutical Factory Inc.
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Nishimura Masuhiro
Div. Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Nishimura Masuhiro
Department Of Drug Metabolism Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceuti
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Nishimura Masuhiro
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Kishimoto Sanae
Division Of Pharmacology Drug Safety And Metabolism Olsuka Pharmaceutical Factory Inc.
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Kishimoto Sanae
大塚製薬工場
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Kishimoto Sanae
Research And Development Center Otsuka Pharmaceutical Factory Inc.
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UEDA Nobuhiko
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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NAITO Shinsaku
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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Naito S
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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山内 あい子
Department Of Pharmaceutical Information Science Graduate School Of Pharmaceutical Science The Unive
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Yamauchi Aiko
Department Of Pharmaceutical Information Science Graduate School Of Pharmaceutical Sciences Universi
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YAMAGUCHI Mari
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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Naito Shinsaku
Research And Development Center Otsuka Pharmaceutical Factory Inc.
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Naito Shinsaku
Res. And Dev. Center Otsuka Pharmaceutical Factory Inc.
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Nishimura Masuhiro
Res. And Dev. Center Otsuka Pharmaceutical Factory Inc.
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Ueda Nobuhiko
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Naito S
Otsuka Pharmaceutical Factory Inc. Tokushima Jpn
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Naito Shinsaku
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Ueda Nobuhiko
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory
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Kishimoto S
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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Ueda N
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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