Influence of Albumin on Enantioselective Local Disposition of BOF-4272,a Xanthine Oxidase Inhibitor with Chiral Sulfoxide, in Rat Liver
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概要
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8-(3-methoxy-4-phenylsulfinylphenyl) pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one (BOF-4272) blocks xanthine oxidase/xanthine dehydrogenase in the liver. BOF-4272 with a sulfoxide chiral center includes R(+)- and S(-)- enantiomers. The enantioselectivity in the global disposition of BOF-4272 can be attributed to that in the local disposition of organs, especially the liver. Thus, the enantioselectivity in the hepatic local disposition of BOF-4272 was compared between R- and S-enantiomers by a hepatic perfusion experiment with a pulse input into the portal vein. The influence of perfusate albumin on the enantioselective local disposition was also investigated. The elution time profile of each BOF-4272 enantiomer from the liver into the hepatic vein was measured at four different bovine serum albumin (BSA) concentrations (0,0.25,1.0 and 4.0%) in the perfusate at 37 and 4℃. A crossover test was carried out for R- and S-enantiomers using one rat liver. In the absence of perfusate BSA at 37℃, hepatic extraction ratios (E_H) of R- and S-enantiomers of BOF-4272 were 75.6±4.3% and 71.7±3.3%, respectively, which were statistically the same. In the presence of 4.0% BSA at 37℃, E_H values of R- and S-enantiomers were 31.7±4.6% and 19.6±3.8%, respectively, which demonstrated that E_H of R-enantiomer was significantly greater than that of S-enantiomer (p<0.001). In the absence and presence of perfusate BSA at 4℃, there was no significant difference in E_H between S- and R-enantiomers. An amplification of stereoselectivity with albumin was observed by the perfusion experiment using BOF-4272 enantiomers.
- 公益社団法人日本薬学会の論文
- 1997-12-15
著者
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NAITO Shinsaku
Research and Development Center, Otsuka Pharmaceutical Factory, Inc.
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Nishimura M
Research And Development Center Otsuka Pharmaceutical Factory Inc.
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Nishimura Masuhiro
Laboratory Of Drug Metabolism Research Naruto Research Institute Otsuka Pharmaceutical Factory Inc.
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Nishimura Masuhiro
Department Of Drug Metabolism Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceuti
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Yamada Kazushi
Department Of Pharmacy:department Of Internal Medicine Kyoto University Hospital Faculty Of Medicine
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YAMAOKA Kiyoshi
Faculty of Pharmaceutical Sciences, Kyoto University
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NAITO Shinsaku
Laboratory of Drug Metabolism Research, Naruto Research Institute, Otsuka Pharmaceutical Factory, In
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NAKAGAWA Terumichi
Faculty of Pharmaceutical Sciences, Kyoto University
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Naito S
Otsuka Pharmaceutical Factory Inc. Tokushima Jpn
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Naito Shinsaku
Laboratory Of Drug Metabolism Research Naruto Research Institute Otsuka Pharmaceutical Factory Inc.
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Nakagawa T
Graduate School Of Pharmaceutical Sciences Kyoto University
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Yamaoka K
Moa Health Science Foundation Life Science Institute
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Nakagawa Terumichi
Faculty Of Pharmaceutical Science Kyoto University
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Yamaoka Kiyoshi
Faculty Of Pharmaceutical Science Kyoto University
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