Introduction of Recirculatory Analysis into Portal and Systemic Concentration Difference Method
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概要
- 論文の詳細を見る
Recirculatory analysis was introduced into the portal and systemic concentration difference method with double dosing (PS-DD method), which is an evaluation system for the local intestinal and hepatic first-pass effect. 5-Fluorouracil (5-FU) and cephalexin (CEX) were selected as model drugs. A new recirculatory system was constructed to predict the time courses of a drug concentration in the systemic and portal bloods. Bioavailability (F), local absorption ratio (F_a), hepatic recovery ratio (F_H), and local mean absorption time (t_a) estimated by recirculatory analysis were close to those calculated by moment analysis with numerical integration. Using recirculatory analysis, the sampling period was considerably shortened and the sampling number was also reduced, which demonstrates that recirculatory analysis is useful in PS-DD method.
- 公益社団法人日本薬学会の論文
- 2001-11-01
著者
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Yamada Kazushi
Department Of Pharmacy:department Of Internal Medicine Kyoto University Hospital Faculty Of Medicine
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Ueda Shigeharu
Research Institute For Microbial Disease Osaka University
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Ueda S
Department Of Gastroenterology And Hepatology Nara Medical University
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Nakagawa T
Graduate School Of Pharmaceutical Sciences Kyoto University
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Yamaoka K
Moa Health Science Foundation Life Science Institute
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Nakagawa Terumichi
Graduate School Of Pharmaceutical Science Kyoto University
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Yamaoka Kiyoshi
Graduate School Of Pharmaceutical Science Kyoto University
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UEDA Shinya
Graduate School of Pharmaceutical Sciences, Kyoto University
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SAWAI Yoneichi
Graduate School of Pharmaceutical Sciences, Kyoto University
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Sawai Yoneichi
Graduate School Of Pharmaceutical Sciences Kyoto University
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