A NEW VERSION OF MULTI (ELS) FOR EXTENDED NONLINEAR LEAST SQUARES

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概要

• 論文の詳細を見る

• A new version of MULTI (ELS) written in BASIC was presented for population pharmacokinetics for microcomputers. The program is provided with four algorithms of extended nonlinear least squares (steepest descent method, quasi-Newton method with DFP formula, quasi-Newton method with BFGS formula and simplex method). Four transformations of parameters can be selected to impose constraints on the parameters (no constraint on a parameter. Pi=Qi^2,Pi=B+(A-B)・sin^2 (Qi) and Pi=B+(A-B)・exp (Qi)/(1+exp (Qi)), where Pi denotes a population mean parameter or variance of inter-and intraindividual variations, Qi is a intermediate parameter, A and B are lower and upper limits of Pi. The definition of a population model and the modifications for BASIC compiler in the new version of MULTI (ELS) are the same as in the old version.

• 公益社団法人日本薬学会の論文

著者

• TANAKA Hisashi

  Faculty of Engineering, University of Miyazaki

• Tanaka H

  Pharmaceutical Development Laboratory Kirin Brewery Co. Ltd.

• Yamaoka Kiyoshi

  Faculty Of Pharmaceutical Science Kyoto University

• Yamaoka K

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Tanaka Hisashi

  Faculty Of Engineering University Of Miyazaki

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