A PHARMACOKINETIC ANALYSIS PROGRAM (MULTI) FOR MICROCOMPUTER
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概要
- 論文の詳細を見る
A nonlinear least squares program (MULTI) for microcomputers was developed. The program is written in BASIC programming language. Four algorithms, (1) Gauss-Newton method, (2) damping Gauss-Newton method, (3) modified Marquardt method and (4) simplex method, can be used for nonlinear curve fitting in MULTI. Up to five pharmacokinetic equations, which are voluntarily defined by the user, are simultaneously fitted to observed time courses. The executions of MULTI are demonstrated for time courses of ampicillin and oxacillin in man.
- 公益社団法人日本薬学会の論文
著者
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Tanigawara Yusuke
Faculty Of Pharmaceutical Sciences Kyoto University
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YAMAOKA Kiyoshi
Faculty of Pharmaceutical Sciences, Kyoto University
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NAKAGAWA Terumichi
Faculty of Pharmaceutical Sciences, Kyoto University
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Nakagawa Terumichi
Faculty Of Pharmaceutical Sciences Kyoto University
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Nakagawa Terumichi
Faculty Of Pharmaceutical Science Kyoto University
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Yamaoka Kiyoshi
Faculty Of Pharmaceutical Science Kyoto University
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UNO TOYOZO
Faculty of Pharmaceutical Sciences, Kyoto University
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Uno Toyozo
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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