COMPARATIVE PHARMACOKINETICS OF DICLOXACILLIN AND AMPICILLIN BETWEEN INDIVIDUAL AND COMBINED DOSES
スポンサーリンク
概要
- 論文の詳細を見る
Pharmacokinetics of dicloxacillin and ampicillin dosed individually and in combination were investigated by means of moment analyses of urinary excretions of intact forms and metabolic products of parent penicillins. Comparison of excretion profiles between individual and combined doses to human subjects indacated that the transformation of ampicillin to penicilloic acid and subsequent conversion to secondary metabolite are suppressed by the simultaneous dose of dicloxacillin, while the total excretion ratio to dose and the mean residence times in the body remain almost unchanged. The excretion profiles of dicloxacillin and metabolites are not significantly affected by the combined dose.
- 公益社団法人日本薬学会の論文
著者
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Murai Yasuo
Faculty Of Pharmaceutical Sciences Kyoto University
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YAMAOKA Kiyoshi
Faculty of Pharmaceutical Sciences, Kyoto University
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NAKAGAWA Terumichi
Faculty of Pharmaceutical Sciences, Kyoto University
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Nakagawa Terumichi
Faculty Of Pharmaceutical Sciences Kyoto University
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Nakagawa Terumichi
Faculty Of Pharmaceutical Science Kyoto University
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Yamaoka Kiyoshi
Faculty Of Pharmaceutical Science Kyoto University
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UNO TOYOZO
Faculty of Pharmaceutical Sciences, Kyoto University
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Uno Toyozo
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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