Perfusion fluids used in neurosurgery affect cerebrospinal fluid and surrounding brain parenchyma in the rat ventriculocisternal perfusion model
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概要
- 論文の詳細を見る
ARTCEREB_[○!R], an irrigation and perfusion solution (Artcereb), is a preparation intended for the irrigation and perfusion of the cerebral ventricles, and it is therefore important to evaluate its effects on cerebrospinal fluid (CSF) and on the surrounding cerebrospinal parenchyma. To confirm the kinetics of the perfusion fluid component, we performed whole body autoradiography and examined glucose balance during ventriculocisternal perfusion with ^<14>C-glucose labeled Artcereb in the rat model, which simulates ventricular irrigation or ventriculocisternal perfusion in clinical neurosurgery. We also performed ventriculocisternal perfusion with Artcereb, lactated Ringer's solution, or normal saline, and observed the effect of these solutions on animal condition and on brain tissue morphology. In the kinetic study, diffusion of ^<14>C-glucose from the perfused Artcereb to the cerebrospinal tissue was seen on whole body autoradiography, and almost 90% of the glucose in the perfusion fluid was distributed to the cerebrospinal tissue and the systemic circulation. These data indicated that the perfusion fluid interacted actively with the CSF, surrounding parenchyma and the systemic circulation, and suggested that the formation of perfusion fluid affected CSF composition and cerebrospinal tissue functions. Animals perfused with normal saline were associated with serious symptoms including tonic convulsions and death, and exhibited neuronal death in the cerebrum. However, these severe changes were not observed in animals perfused with Artcereb or lactated Ringer's solution. We therefore propose that during neurosurgery, it is extremely important to use a physiological solution like Artcereb which closely resembles normal human CSF, in order to maintain cerebrospinal function and to alleviate postoperative adverse events.
- 日本トキシコロジー学会の論文
- 2009-10-01
著者
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山内 あい子
徳島大学薬学部
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YAMAUCHI Aiko
Department of Pharmaceutical Information Science, Graduate School of Pharmaceutical Sciences, Univer
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NISHIMURA Masuhiro
Research and Development Center, Otsuka Pharmaceutical Factory, Inc.
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DOI Kazuhisa
Research and Development Center, Otsuka Pharmaceutical Factory, Inc.
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NAITO Shinsaku
Research and Development Center, Otsuka Pharmaceutical Factory, Inc.
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Nishimura M
Research And Development Center Otsuka Pharmaceutical Factory Inc.
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Nishimura Masuhiro
Div. Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Nishimura Masuhiro
Department Of Drug Metabolism Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceuti
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Doi Kazuhisa
Research And Development Center Otsuka Pharmaceutical Factory Inc.
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Nishimura Masuhiro
Research And Development Center Otsuka Pharmaceutical Factory Inc.
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Harada Daisuke
Research And Development Center Otsuka Pharmaceutical Factory Inc.
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Harada Daisuke
協和発酵工業医薬研究センター 探索研究所･薬理研究所
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山内 あい子
Department Of Pharmaceutical Information Science Graduate School Of Pharmaceutical Science The Unive
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Yamauchi Aiko
Department Of Pharmaceutical Information Science Graduate School Of Pharmaceutical Sciences Universi
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Kawano Takeshi
Research And Development Center Otsuka Pharmaceutical Factory Inc.
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Morioka Yujiro
Research and Development Center, Otsuka Pharmaceutical Factory, Inc.
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Kamataki Tetsuya
日本農産工業
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Morioka Yujiro
Research And Development Center Otsuka Pharmaceutical Factory Inc.
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Naito Shinsaku
Research And Development Center Otsuka Pharmaceutical Factory Inc.
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Naito Shinsaku
Res. And Dev. Center Otsuka Pharmaceutical Factory Inc.
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Nishimura Masuhiro
Res. And Dev. Center Otsuka Pharmaceutical Factory Inc.
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Naito S
Otsuka Pharmaceutical Factory Inc. Tokushima Jpn
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Harada Daisuke
Pharmacological Research Laboratories Kyowa Hakko Kirin Co. Ltd.
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