Soybean Oil Fat Emulsion Prevents Cytochrome P450 mRNA Down-Regulation Induced by Fat-Free Overdose Total Parenteral Nutrition in Infant Rats(Biopharmacy)
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概要
- 論文の詳細を見る
Changes in the mRNA expression of hepatic cytochrome P450 (CYP) isoenzymes associated with overdose of fat-free or fat-containing total parenteral nutrition (TPN) were investigated in infant rats. Three-week-old male Sprague-Dawley rats were divided into three groups : group 1 received an oral diet, group 2 received TPN without fat, and group 3 received TPN with 20% of calories from fat (soybean oil emulsion). After TPN administration for 4d, serum aspartate aminotransferase (AST) levels in group 2 were significantly increased (p<0.01) compared with the other groups. The mRNA expression of hepatic CYP isoenzymes in group 2 decreased to 0.76 to 31% of that in group 1 (p<0.01), but that in group 3 was maintained at 32 to 84% of that in group 1. These results indicate the importance of including fat in TPN regimens to prevent not only hepatic dysfunction but also mRNA down-regulation of liver CYP isoenzymes.
- 公益社団法人日本薬学会の論文
- 2005-01-01
著者
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YAMAUCHI Aiko
Department of Pharmaceutical Information Science, Graduate School of Pharmaceutical Sciences, Univer
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NAITO Shinsaku
Research and Development Center, Otsuka Pharmaceutical Factory, Inc.
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Nishimura M
Research And Development Center Otsuka Pharmaceutical Factory Inc.
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Nishimura Masuhiro
Department Of Drug Metabolism Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceuti
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Nishimura Masuhiro
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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UEDA Nobuhiko
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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NAITO Shinsaku
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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Naito S
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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山内 あい子
Department Of Pharmaceutical Information Science Graduate School Of Pharmaceutical Science The Unive
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Yamauchi Aiko
Department Of Pharmaceutical Information Science Graduate School Of Pharmaceutical Sciences Universi
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YAMAGUCHI Mari
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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Naito Shinsaku
Research And Development Center Otsuka Pharmaceutical Factory Inc.
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Naito Shinsaku
Res. And Dev. Center Otsuka Pharmaceutical Factory Inc.
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Ueda Nobuhiko
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Naito S
Otsuka Pharmaceutical Factory Inc. Tokushima Jpn
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Naito Shinsaku
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Ueda Nobuhiko
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory
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Ueda N
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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Nishimura Masahiro
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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