ADRENERGIC MECHANISM IN <I>TETRAHYMENA</I> II EFFECT OF ADRENALINE ON CELL PROLIFERATION
スポンサーリンク
概要
- 論文の詳細を見る
Growth of <I>Tetrahymena</I> in the exponential phase was slightly accelerated by transfer of cells to a medium containing 10<SUP>-3</SUP>-10<SUP>-5</SUP> M adrenaline or noradrenaline, while that of stationary phase cells was inhibited by 10<SUP>-3</SUP>-10<SUP>-7</SUP> M catecholamine. In synchronized cultures of Tetrahymena, adrenaline inhibited RNA and protein syntheses in both the late G<SUB>1</SUB> and the G<SUB>2</SUB> phases. These inhibitory effects in the late G<SUB>1</SUB> and G<SUB>2</SUB> phases result in an inhibition of the introduction of the S phase and of cytokinesis, respectively. These results indicate that an adrenergic mechanism in Tetrahymena plays a role in regulating the cell cycle.
- 公益社団法人 日本薬理学会の論文
著者
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Kariya Kimio
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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Iwata Heitaroh
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
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KARIYA Kimio
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
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WADA Yutaka
Pharmaceutical Research Laboratory, Sakai Chemical Industry Co., Ltd.
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