PHARMACOLOGICAL STUDIES ON NITROGEN MUSTARD-N-OXIDES

概要

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The halogenated alkylamines, so called nitrogen mustards (NM) investigated during the last World War as a potential warfare agent, have become useful tools in biology and medicine for their ability to increase the spontaneous mutation rate in plants and animals (1) and to palliate leukemia, lymphoma and lung carcinoma (2). Recently, Ishidate et al, (3) have paid attention to the lower toxicity of nitrogen mustard-N-oxides (NMO) which had been prepared by Stahmann (4) in 1946 comparing to their original amines, and demonstrated that methyl-bis-β-chloroethylamine-N-oxide (MBAO, Nitromin) had an equal inhibitory potency to methyl-bis-β-chloroethylamine (MBA) on Yoshida-sarcoma. Meanwhile, on the pharmacology of NM, many studies had been done, as seen in the review of Phillips (5), but no pharmacological research has yet been made about NMO. The purpose of the present paper is to determine the pharmacological properties of NMO, especially of Nitromin, and of the correlation with their original amines.
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