Y-931, a Novel Atypical Antipsychotic Drug, Is Less Sensitive to Oxidative Phenomena
スポンサーリンク
概要
- 論文の詳細を見る
The oxidation behavior of Y-931, a potent atypical antipsychotic drug, was compared with that of clozapine and olanzapine. In two enzymatic systems (horseradish peroxidase (HRP)/glutathione (GSH) and HRP/H_2O_2/GSH) which generate thiyl radicals, clozapine markedly strengthened the electron paramagnetic resonance (EPR) signal for the radical. Olanzapine, Y-931 and the major metabolites (compounds 1-3) had no or minimal effect on the intensity of this signal. In addition, the redox potential values for the three derivatives were in accord with the EPR spin trapping results. In toxicological experiments in human leukocytes, a concentration-dependent toxicity was observed when neutrophils were incubated with clozapine (1-10 μmol/l) and H_2O_2 (1 mmol/l). However, Y-931 and olauzapine did not show remarkable toxicity under the conditions.
- 公益社団法人日本薬学会の論文
- 2002-06-01
著者
-
YAMAMOTO IWAO
Department of Functional Polymer Science, Faculty of Textile Science and Technology, Shinshu Univers
-
Maeda Junichi
Exploratory Research I (cns) Pharmaceuticals Research Division Mitsubishi Pharma Corporation
-
KOHARA Toshiyuki
Exploratory Research I (CNS), Pharmaceuticals Research Division, Mitsubishi Pharma Corporation
-
KOYAMA Toshiki
Department of Functional Polymer Science, Faculty of Textile Science and Technology, Shinshu Univers
-
FUJIMURA Masatake
Exploratory Research I (CNS), Pharmaceuticals Research Division, Mitsubishi Pharma Corporation
-
TANAKA Hiroshi
Exploratory Research I (CNS), Pharmaceuticals Research Division, Mitsubishi Pharma Corporation
-
FUJIMOTO Tetsuya
Department of Functional Polymer Science, Faculty of Textile Science and Technology, Shinshu Univers
-
ARITA Masafumi
Exploratory Research I (CNS), Pharmaceuticals Research Division, Mitsubishi Pharma Corporation
-
Tanaka Hiroyoki
Faculty Of Pharmaceutical Sciences Kyushu University
-
FUJIMOTO Tetsuya
Faculty of Textile Science and Technology, Shinshu University
-
Yamamoto I
Faculty Of Textile Science And Technology Shinshu University
-
Koyama Toshiki
Department Of Functional Polymer Science Faculty Of Textile Science And Technology Shinshu Universit
-
Arita Masafumi
Exploratory Research I (cns) Pharmaceuticals Research Division Mitsubishi Pharma Corporation
-
Fujimura M
Exploratory Research I (cns) Pharmaceuticals Research Division Mitsubishi Pharma Corporation
-
Fujimoto T
Faculty Of Textile Science And Technology Shinshu University
-
Yamamoto Iwao
Department Of Functional Polymer Science Faculty Of Textile Science And Technology Shinshu Universit
-
Fujimoto Tetsuya
Department Of Chemistry Faculty Of Science Yamagata University
-
Yamamoto Iwao
Department of Chemistry, Shinshu University at Ueda
関連論文
- Evaluation of depth distribution function for AR-XPS using synchrotron radiation hard X-ray (Extended abstracts book of the International Workshop for Surface Analysis and Standardization '09 (iSAS-09))
- Cloning and sequencing of cDNAs encoding walleye pollack α-skeletal actin isoforms
- Relationship between Balance Performance and Leg Muscle Strength in Elite and Non-Elite Junior Speed Skaters
- Effect of Ageing on Quadriceps Muscle Strength and on the Forward Shift of Center of Pressure during Sit-to-stand Movement from a Chair
- Purification and Some Characteristics of a Monomeric Alanine Racemase from an Extreme Thermophile, Thermus thermophilus
- Y-931, a Novel Atypical Antipsychotic Drug, Is Less Sensitive to Oxidative Phenomena
- Effect of Bite with and without Dentures on Soleus H-Reflex in the Elderly
- Formation of Singlet Oxygen-Like Active Oxygen Species in System Containing Nickel(II) Complex and Aliphatic Aldehyde
- Different Coronary Blood Flow Increase in Left Ventricular Hypertrophy Due to Hypertension Compared to Hypertrophic Cardiomyopathy at Elevated Heart Rate
- Preparation of Optically Active Succinic Acid Derivatives. II. Efficient and Practical Synthesis of KAD-1229
- Preparation of Optically Active Succinic Acid Derivatives. I. Optical Resolution of 2-Benzyl-3-(cis-hexahydroisoindolin-2-ylcarbonyl)-propionic Acid
- 4-(Benzoylindolizinyl)butyric Acids ; Novel Nonsteroidal Inhibitors of Steroid 5α-Reductase. III.^
- Curtisians M-Q: Five Novel p-Terphenyl Derivatives from the Mushroom Paxillus curtisii
- Two Novel Ravenelones from the Edible Mushroom Pulveroboletus ravenelii
- Simultaneous analysis of human plasma catecholamines by high-performance liquid chromatography with a reversed-phase triacontylsilyl silica column
- Rat small hepatocytes for liver support : growth and metabolic activities in culture
- Maintenance of morphology and function of mixed liver cell spheroids under collagen gel environment
- Two New Steroidal Saponins from "Gualou-xiebai-baijiu-tang" Consisting of Fructus trichosanthis and Bulbus allii macrostemi
- Crystal Structure of the Pyridoxal 5'-phosphate Dependent L-Methionine γ-Lyase from Pseudomonas putida
- Preparation and Characterization of Insulin-Loaded Acrylic Hydrogels Containing Absorption Enhancers
- Quantitative Evaluation of the Bitterness of Commercial Medicines Using a Taste Sensor
- New Ionic Conducting Polymer Composite Films Based on Partially Phosphorylated Poly(vinyl alcohol)and Poly(acrylic acid)
- Role of Tyrosine 114 of L-Methionine γ-lyase from Pseudomonas putida
- Asymmetric Borane Reduction of Prochiral Ketone Using Chiral Bis(α,α-diphenyl-2-pyrrolidinemethanol) Carbonate
- The Practical Synthesis of a Uterine Relaxant, Bis(2-{[(2S)-2-({(2R)-2-hydroxy-2-[4-hydroxy-3-(2-hydroxyethyl)-phenyl]ethyl}amino)-1, 2, 3, 4-tetrahydronaphthalen-7-yl]oxy}-N, N-dimethylacetamide)Sulfate(KUR-1246)
- The Practical Synthesis of(2S)-7-Methoxy-1, 2, 3, 4-tetrahydro-2-naphthylamine via Optical Resolution of 2-(3-Methoxybenzyl)succinic Acid
- Solid-Phase Tandem Radical Addition-Cyclization Reaction : Triethylborane-Induced Reaction of Oxime Ethers Anchored to Polymer Support
- Physical and Chemical Properties of an Extracellular Low-Molecular-Weight Substance from the Brown-Rot Basidiomycete Fomitopsis palustris
- Stannyl Radical Addition-Cyclization of Oxime Ethers Connected with Olefins
- Recombinant Expression, Biochemical Characterization and Stabilization through Proteolysis of an L-Glutamate Oxidase from Streptomyces sp. X-119-6
- Role and Behavior of Benthic Microbes Able to Degrade Herbicide Atrazine in Naturally Derived Water/sediment Microcosm
- Bilirubin Dehydrogenase, an Enzyme in Aspergillus ochraceus IB-3 Useful for Diagnostic Measurement of Bilirubin(Microbiology & Fermentation Technology)
- Evaluation of Myopathy Risk for HMG-CoA Reductase Inhibitors by Urethane Infusion Method
- Purification and Characterization of an Acid Trehalase from Acidobacterium capsulatum
- State of Tryptophyl Residues and Stability of Recombinant Human Matrix metalloproteinase 7 (Matrilysin) as Examined by Fluorescence^1
- Organic Thin-Film Transistors with Conductive Metal-Oxides as Source-Drain Electrodes
- Light Emission from Organic Single-Crystal Field-Effect Transistors
- Electroluminescence Spikes of Pulsed Organic Light-Emitting Diodes at Switch-Off Using 1, 4-Bis[2-[4-[N, N-di(p-tolyl)amino]phenyl]vinyl]benzene as a Light-Emitting Layer
- Use of Trapezoid Pulse Voltage in Study of Transient Response of Organic Light-Emitting Diodes
- Organic Field-Effect Transistor of (Thiophene/Phenylene) Co-Oligomer Single Crystals with Bottom-Contact Configuration
- Relationship between Molecular Skeleton and Stimulated-emission Threshold in Dilute Thin Films of Linear-chain-structured Fluorescent Dyes
- Method of Measuring Charge Carrier Mobility in Organic Light-Emitting Diodes Using Fast Transient Electroluminescence Responses (Short Note)
- Synthesis and Fungicidal Activities of Silicon-Containing Derivatives of 2-Aryl-3-(1H-1, 2, 4, -triazol-1-yl)propanenitriles
- Sagittal Kinematics and Muscular Activities of Torso and Hip during Trunk Flexion and Extension
- Low-Threshold Photopumped Distributed Feedback Plastic Laser Made by Replica Molding
- Exciton Dynamics in Organic Semiconductor Devices : Investigation of Exciton-Charge Carrier Interactions as Revealed by Photoluminescence Responses(Atoms, Molecules, Chemical Physics)
- Photopumped Organic Solid-State Dye Laser with a Second-Order Distributed Feedback Cavity : Optics and Quantum Electronics
- Organic Light-Emitting Devices Patterned by Screen-Printing
- Improved Recovery of Human Urinary Protein for Electrophoresis
- Low Threshold Gain-Narrowing Characteristics of Fluorescent Styrylbenzene Derivatives as a Guest Molecule in an Organic Thin-Film Optical Waveguide
- A High Voltage Dye-sensitized Solar Cell using a Nanoporous NiO Photocathode
- Organic Light Emitting Diodes Using Triphenylene Derivatives as a Hole Transport Material
- Submicrometer-Sized Organic Light Emitting Diodes with a Triphenylamine-Containing Polycarbonate as a Guest Molecule in a Polymer Blend
- Electroluminescence Spikes of Pulsed Organic Light-Emitting Diodes at Switch-Off Using 1,4-Bis[2-[4-[N,N-di($ p$-tolyl)amino]phenyl]vinyl]benzene as a Light-Emitting Layer
- Use of Trapezoid Pulse Voltage in Study of Transient Response of Organic Light-Emitting Diodes
- Functional Metallomacrocycles and Their Polymers XXXIII. Autoxidation of Thiol Catalyzed by Thermoelastic Polyurethane Resin Containing a Cobalt(II)phthalocyanine
- The Influence of Thermotherapy on Muscle Elasticity : Measurement of Pennation Angle with the Use of Ultrasound Images
- EFFECT OF SODIUM ION ON LEVELS OF CYCLIC ADENOSINE 3, 5-MONOPHOSPHATE IN GUINEA PIG CEREBRAL SLICES
- ACTION OF TYRAMINE ON THE SALIVARY AMYLASE SECRETION FROM RABBIT PAROTID GLAND IN REFERENCE TO THAT OF NICOTINE
- Synthesis of 1-Nonene from Decanoic Acid by Polymer-Bound Palladium Complexes
- Sex differences in odor-responding neurons of the rat medial amygdaloid area
- INCORPORATION OF 32P INTO PHOSPHOLIPIDS OF THE ADRENAL MEDULLA DURING AND AFTER STIMULATION BY SECRETOGOGUES
- Visualization of Impinging Supersonic Free Jet on a Tilt Plate by LIF and PSP
- Mechanisms of NK cell activation stimulated by CD2 : granzyme B is released by CD2 crosslinking-stimulation on NK92 cells
- Photoluminescence and Optical Gain Properties of a Crystalline Thiophene/Phenylene Co-oligomer
- Organic Field-Effect Transistor of (Thiophene/Phenylene) Co-Oligomer Single Crystals with Bottom-Contact Configuration
- Ablation of rat substantia nigra may provide a good acute model of Parkinson's disease for stem cell transplantation
- Light Emission from Organic Single-Crystal Field-Effect Transistors
- PHARMACOLOGICAL EVALUATIONS OF BIS-β-CHLOROETHYLAMINE COMPOUNDS
- PHARMACOLOGICAL STUDIES ON NITROGEN MUSTARD-N-OXIDES
- EFFECTS OF NITROMIN, MITOMYCIN C AND CHROMOMYCIN A3 ON THE TESTIS AND HEMATOPOIETIC ORGAN IN MICE AND RATS
- Molecular structures of adducts of benzoyl isothiocyanate and hydrazones determined by the X-ray diffraction method.
- EFFECT OF CHLORPROMAZINE ON ENZYMIC REACTIONS INVOLVING METAL IONS
- CATECHOLAMINE SECRETION FROM THE ADRENAL GLAND TREATED WITH NEURAMINIDASE, PROTAMINE OR ALKYLATING AGENT
- A NOTE ON cis-UROCANIC ACID
- Mechanisms of NK cell activation stimulated by CD2 ; granzyme B is released by CD2 crosslinking-stimulation on NK92 cells