Quantitative Evaluation of the Bitterness of Commercial Medicines Using a Taste Sensor

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概要

• 論文の詳細を見る

• The bitterness of 11 commercial medicines was evaluated both by a multichannel taste sensor and in human gustatory sensation tests with 15 volunteers. For basic drugs with amino groups in the molecule, such as quinine, there was a comparatively strong relative response electric potential (mV) of channels 1 or 2,those containing negatively charged membranes and the bitterness determined by human gustatory sensation tests. The suppression of the bitterness of quinine by sucrose and aspartame could be quantified using the artificial taste sensor and the results concurred with those from gustatory sensation tests. The usefulness of the sensor was thus confirmed for this type of compound.Anionic drugs, such as diclofenac sodium or salicylic acid gave rise in a negative response electric potential in channels 5 or 6,those containing positively charged membrane, seemed to be useful information even though their tastes are being sour rather than bitter.For drugs with both an amino (cationic) group and carboxylic acid (anionic) group in the moelcule, such as theophylline, caffeine, and metronidazole, the relative response electric potential (mV) of channels containing negatively charged membranes was not increased, even though bitterness was observed in human gustatory sensation tets. Therefore, a different design of membrane component is required for more general evaluation of the bitterness of various medicines.

• 公益社団法人日本薬学会の論文
• 2000-11-01

著者

• MIYANAGA Yohko

  School of Pharmaceutical Sciences, Mukogawa Women's University

• MATSUYAMA Kenji

  School of Pharmaceutical Sciences, Mukogawa Women's University

• UCHIDA Takahiro

  School of Pharmaceutical Sciences, Mukogawa Women's University

• Tanaka H

  Faculty Of Pharmacy Meijo University

• Miyanaga Y

  School Of Pharmaceutical Sciences Mukogawa Women's University

• Miyanaga Yohko

  School Of Pharmaceutical Sciences Mukogawa Women's University

• Wada K

  Kawanishi Pharma Research Institute Nippon Boehringer Ingelheim Co. Ltd.

• Wada K

  Nagoya Inst. Technol. Nagoya‐shi Jpn

• Tanaka H

  Department Of Agricultural Chemistry Faculty Of Agriculture Utsunomiya University

• Yoshida Makiko

  Aoyama Daini Hospital

• Tanaka H

  Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University

• Tanaka H

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Matsuyama Kenji

  School Of Pharmaceutical Sciences Mukogawa Women's University

• Matsuyama Kenji

  Department Of Hospital Pharmacy Nagasaki University Hospital:faculty Of Pharmaceutical Sciences Kyus

• Matsuyama Kenji

  Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Toyama Hirohide

  Institute For Chemical Research Kyoto University

• Tanaka Haruyuki

  Chemical Branch Faculty Of Engineering And Kansai University High Technology Research Center Kansai

• Uchida Takahiro

  School Of Pharmaceutical Sci. Mukogawa Women's Univ.

• TANAKA Hiromi

  School of Pharmaceutical Sciences, Mukogawa Women's University

• WADA Koichi

  Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.,

• KUROSAKI Seisuke

  Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.,

• OHKI Toshimitsu

  Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.,

• WADA Koichi

  Biotechnology Research Center, Toyama Prefectural University

• Tanaka Hiroyoki

  Faculty Of Pharmaceutical Sciences Kyushu University

• Ohki Toshimitsu

  Kawanishi Pharma Research Institute Nippon Boehringer Ingelheim Co. Ltd.

• Wada K

  Biotechnology Research Center Toyama Prefectural University

• Wada Koichi

  The Department Of Electrical And Computer Engineering Nagoya Institute Of Technology

• Kurosaki Seisuke

  Kawanishi Pharma Research Institute Nippon Boehringer Ingelheim Co. Ltd.

• TANAKA Hiromi

  Department of Physics Faculty of Education, Saga University

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