Synthesis of Optically Active 1,4-Thiazane-3-carboxylic Acid via Optical Resolution by Preferential Crystallization of (RS)-2-Amino-3-[(2-chloroethyl) sulfanyl] propanoic Acid Hydrochloride
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概要
- 論文の詳細を見る
Optically active 1,4-thiazane-3-carboxylic acid [TCA] was synthesized from cysteine via optical resolution by preferential crystallization. The intermediate (RS)-2-amino-3-[(2-chloroethyl) sulfanyl] propanoic acid hydrochloride [(RS)-ACS・HCl] was found to exist as a conglomerate based on its melting point, solubility and IR spectrum. (RS)-ACS・HCl was optically resolved by preferential crystallization to yield (R)-and (S)-ACS・HCl. (R)-and (S)-ACS・HCl thus obtained were recrystallized from a mixture of hydrochloric acid and 2-propanol, taking account of the solubility of (RS)-ACS・HCl, efficiently yielding both enantiomers in optically pure forms. (R)-and (S)-TCA were then respectively synthesized by the cyclization of (R)-and (S)-ACS・HCl in ethanol in the presence of triethylamine.
- 社団法人日本農芸化学会の論文
- 1998-12-23
著者
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Tanaka H
Faculty Of Pharmacy Meijo University
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Kubo M
Unit Of Chemistry Faculty Of Engineering Kansai University
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Kubo Motoki
Unit Of Chemistry Faculty Of Engineering Kansai University
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SHIRAIWA Tadashi
Unit of Chemistry, Faculty of Engineering, Kansai University
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SHIRAIWA Tadashi
Chemical Branch, Faculty of Engineering and Kansai University High Technology Research Center, Kansa
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TADOKORO Kohya
Chemical Branch, Faculty of Engineering and Kansai University High Technology Research Center, Kansa
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TANAKA Haruyuki
Chemical Branch, Faculty of Engineering and Kansai University High Technology Research Center, Kansa
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KUROKAWA Hidemoto
Chemical Branch, Faculty of Engineering and Kansai University High Technology Research Center, Kansa
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Toyama Hirohide
Institute For Chemical Research Kyoto University
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Tadokoro Kohya
Chemical Branch Faculty Of Engineering And Kansai University High Technology Research Center Kansai
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Tanaka Haruyuki
Chemical Branch Faculty Of Engineering And Kansai University High Technology Research Center Kansai
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Kurokawa Hidemoto
Chemical Branch Faculty Of Engineering And Kansai University High Technology Research Center Kansai
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Kurokawa Hidemoto
Chemical Branch Faculty Of Engineering And High Technology Research Center Kansai University
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NANBA Keiichiro
Chemical Branch, Faculty of Engineering and Kansai University High Technology Research Center, Kansa
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YOKONO Noriyoshi
Chemical Branch, Faculty of Engineering and Kansai University High Technology Research Center, Kansa
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SHIBAZAKI Katsuyoshi
Chemical Branch, Faculty of Engineering and Kansai University High Technology Research Center, Kansa
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KUBO Motoki
Chemical Branch, Faculty of Engineering and Kansai University High Technology Research Center, Kansa
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Nanba Keiichiro
Chemical Branch Faculty Of Engineering And Kansai University High Technology Research Center Kansai
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Yokono Noriyoshi
Chemical Branch Faculty Of Engineering And Kansai University High Technology Research Center Kansai
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Shibazaki Katsuyoshi
Chemical Branch Faculty Of Engineering And Kansai University High Technology Research Center Kansai
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Shiraiwa Tadashi
Unit Of Chemistry Faculty Of Engineering Kansai University
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Shiraiwa T
Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University
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Shiraiwa Tadashi
Chemical Branch Faculty Of Engineering And High Technology Research Center Kansai University
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Kurokawa Hidemoto
Chemical Branch Faculty Of Engineering And Kansai University High Technology Research Center Kansai
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TANAKA Hiromi
Department of Physics Faculty of Education, Saga University
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