Synthesis of Optically Active Homocysteine from Methionine and Its Use in Preparing Four Stereoisomers of Cystathionine
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概要
- 論文の詳細を見る
In order to synthesize four stereoisomers of cystathionine (CYT), D- and L-homocysteines (D- and L-Hcy) were synthesized from methionine (Met) by a facile procedure. L-Met was reacted with dichloroacetic acid in concentrated hydrochloric acid under reflux to give (4S)-1,3-thiazane-2,4-dicarboxylic acid hydrochloride [(4S)-TDC・HCl]. L-Hcy was obtained by treatment of (4S)-TDC・HCl with hydroxylamine. D-Hcy was also synthesized from D-Met via (4R)-TDC・HCl intermediate. The obtained D- and L-Hcy were condensed with (R)- and (S)-2-amino-3-chloropropanoic acid hydrochlorides under alkaline conditions to give four stereoisomers of CYT.
- 公益社団法人日本薬学会の論文
- 2002-08-01
著者
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SHIRAIWA Tadashi
Unit of Chemistry, Faculty of Engineering, Kansai University
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Nakagawa K
Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University
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Shiraiwa T
Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University
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Shiraiwa Tadashi
Unit Of Chemistry Fac. Of Engineering And High Technol. Res. Center Kansai Univ.
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NAKAGAWA Kazuo
Unit of Chemistry, Faculty of Engineering and High Technology Research Center, Kansai University
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KANEMOTO Norito
Unit of Chemistry, Faculty of Engineering and High Technology Research Center, Kansai University
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KINDA Tomohiro
Unit of Chemistry, Faculty of Engineering and High Technology Research Center, Kansai University
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YAMAMOTO Hiroki
Unit of Chemistry, Faculty of Engineering and High Technology Research Center, Kansai University
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Kinda Tomohiro
Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University
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Kanemoto Norito
Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University
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Yamamoto Hiroki
Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University
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