Optical Resolution by Preferential Crystallization of (1RS, 3RS)-1,2,3,4-Tetrahydro-6,7-dihydroxy-1-methyl-3-isoquinolinecarboxylic Acid
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概要
- 論文の詳細を見る
The racemic structure of (1RS, 3RS)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-methyl-3-isoquinolinecarboxylic acid [(1RS, 3RS)-1] was examined based on the melting point, solubility, and IR spectrum, with the aim of optical resolution by preferential crystallization. (1RS, 3RS)-1 was indicated from these results to exist as a conglomerate. The successive optical resolution by preferential crystallization of (1RS, 3RS)-1 yielded (1S, 3S)- and (1R, 3R)-1 with optical purities of 85-95% at 66-81% degrees of resolution, which were fully purified by recrystallization.
- 公益社団法人日本薬学会の論文
- 2005-09-01
著者
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Shiraiwa Tadashi
Unit Of Chemistry Fac. Of Engineering And High Technol. Res. Center Kansai Univ.
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KIYOE Ryuuichi
Unit of Chemistry, Faculty of Engineering and High Technology Research Center, Kansai University
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Kiyoe Ryuuichi
Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University
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