Factors Associated with Phlebitis and Venous Pain due to Intravenous Injection of Epirubicin Hydrochloride
スポンサーリンク
概要
- 論文の詳細を見る
Anthracyclines play an important role in the treatment of breast cancer and various regimens containing doxorubicin (A) and epirubicin hydrochloride (E), e.g., AC (doxorubicin+cyclophosphamide), EC (epirubicin hydrochloride+cyclophosphamide), and FEC (fluorouracil+epirubicin+cyclophosphamide) are widely used in clinical oncology. However, anthracyclines frequently cause inflammation or pain at the site of injection and along blood vessels. To determine the cause of phlebitis and venous pain due to these agents, we designed an experimental study to investigate factors considered to be associated with these symptoms, such as titratable acidity, osmotic pressure, and pH, for the 2 epirubicin preparations available for the FEC regimen: Farmorubicin^[○!R] (freeze-dried formulation) and Farmorubicin^[○!R] RTU (ready-to-use injection solution). We compared Farmorubicin^[○!R] and Farmorubicin^[○!R] RTU when diluted with various concentrations of saline, 5% glucose, and distilled water, and with or without dexamethasone. The titratable acidity of Farmorubicin^[○!R] RTU was 3.4mEq/L, far less than the 7mEq/L reported to sometimes cause phlebitis and venous pain, which suggests that the titratable acidity of Farmorubicin^[○!R] RTU is not connected with phlebitis or venous pain. The pHs of Farmorubicin^[○!R], Farmorubicin^[○!R] RTU and dexamethasone were 4.5 to 6.0, 2.5 to 3.5, and 7.0 to 8.5, respectively. The osmotic pressures of Farmorubicin^[○!R], Farmorubicin^[○!R] RTU, and dexamethasone were all 282mOsm/kg. Thus pH could be modified by adding small amounts of dexamethasone, which is normally used prior to FEC therapy to avoid nausea, vomiting, and hypersensitivity to Farmorubicin^[○!R] RTU, and doing this might prevent the phlebitis and venous pain that occur during injection of Farmorubicin^[○!R] RTU.
- 日本医療薬学会の論文
- 2006-11-10
著者
-
MASUDA NORIKAZU
Department of Surgery, National Hospital Organization, Osaka National Hospital
-
MATSUYAMA Kenji
School of Pharmaceutical Sciences, Mukogawa Women's University
-
Matsuyama Kenji
School Of Pharmaceutical Sciences Mukogawa Women's University
-
Masuda Norikazu
Department Of Surgery National Hospital Organization Osaka National Hospital
-
Masuda Norikazu
Department Of Surgery National Osaka Medical Center
-
Nishikata Mayumi
School Of Pharmaceutical Sciences Mukogawa Women's University
-
Matsuyama Kenji
関西医科大学附属滝井病院 薬剤部
-
Anami Setsuko
Department of Pharmacy, Sakai Municipal Hospital
-
Anami Setsuko
Department Of Pharmacy Sakai Municipal Hospital
-
Nishikata Mayumi
School of Pharmaceutical Sciences, Mukogawa Women's University
関連論文
- An Icteric Type Hepatocellular Carcinoma with No Detectable Tumor in the Liver : Report of a Case
- The Bitterness Intensity of Clarithromycin Evaluated by a Taste Sensor
- Effect of Quinine Solutions on Intracellular Ca^Levels in Neuro-2a Cells : Conventional Physiological Method for the Evaluation of Bitterness(Miscellaneous)
- Clinical Efficacy of Shitei-decoction for Hiccups
- The Effect of Various Substances on the Suppression of the Bitterness of Quinine-Human Gustatory Sensation, Binding, and Taste Sensor Studies
- A New Method for Evaluating the Bitterness of Medicines by Semi-continuous Measurement of Adsorption Using a Taste Sensor
- Preparation and Characterization of Insulin-Loaded Acrylic Hydrogels Containing Absorption Enhancers
- Quantitative Evaluation of the Bitterness of Commercial Medicines Using a Taste Sensor
- Preparation and Characterization of Acrylic Hydrogels Neutralized by Basic Amino Acids
- Evaluation of Myopathy Risk for HMG-CoA Reductase Inhibitors by Urethane Infusion Method
- Zero-Order Release from Cylindrical Xerogel Preparation
- Factors Associated with Phlebitis and Venous Pain due to Intravenous Injection of Epirubicin Hydrochloride
- Preliminary result of accelerated partial breast irradiation after breast-conserving surgery
- Preparation and Characterization of Polylactic Acid Microspheres Containing Water-Soluble Anesthetics with Small Molecular Weight
- Statistical analysis of the adverse effects of glycopeptide antibiotics, based on pharmacokinetics and toxicokinetics (PK/TK)
- Predictive factors for anthracycline-based chemotherapy for human breast cancer
- An Attempt to Evaluate the Effect of Vitamin K_3 Using as an Enhancer of Anticancer Agents(Pharmacology)
- Preparation and Characterization of Polylactic Acid Microspheres Containing Bovine Insulin by a w/o/w Emulsion Solvent Evaporation Method
- Effect of Cholestyramine on the Pharmacokinetics and Pharmacodynamics of Bezafibrate in Rats
- ENHANCED MYOPATHY FOLLOWING ADMINISTRATION OF HYPOLIPIDEMIC AGENTS UNDER URETHANE ANESTHESIA
- Drug Interaction between Simvastatin and Cholestyramine in Vitro and in Vivo
- Usefulness of Questions from Patients and Their Families in Medication Guidance : Role of the Pharmacist in Integrated Therapy for Blood Cancer
- Clinical usefulness of high-dose toremifene in patients relapsed on treatment with an aromatase inhibitor
- Ki67 index changes, pathological response and clinical benefits in primary breast cancer patients treated with 24 weeks of aromatase inhibition
- Phase II study of bi-weekly irinotecan for patients with previously treated HER2-negative metastatic breast cancer : KMBOG0610B