EFFECT OF CHLORPROMAZINE ON THE CELL METABOLISM

概要

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Since H. Laborit (1) had been successful in "l'hibernation artificielle" with chlorpromazine and S. Courvoisier et al. (2) had reported the pharmacological properties of the drug, the possible therapeutic usefullness have been attempted for the treatment of neuropsychiatric disorders and the other diseases. On the other hand, a few information could be found on the effect of chlorpromazine on the cell metabolism. A. Balesterieri (3) reported that the glucose oxidation was inhibited more eminently by the drug than phenobarbital, but the succinate oxidation was not affected. L. Perruzzo et al. (4) pointed out that the oxygen consumption of the brain slice in the chlorpromazine solution was reduced. F. Decourt et al. (5) showed that the fermentation of alcohol by yeast was not inhibited by the lower concentration of chlorpromazine and the phosphorylation in the fermentation was not affected. Having been very much interested in the extensive clinical application of chlorpromazine without a satisfactory investigation of the effect on the cell metabolism, we have made an attempt at the study on the effect of this drug on the cell respiration.
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