Serum-Deprivation Induces Cell Death of Rat Cultured Microglia Accompanied With Expression of Bax Protein
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概要
- 論文の詳細を見る
Expression of Bcl−2 related proteins in rat microglial primary culture was examined.At relative low cell densities, serum deprivation caused cell death and nuclei condensation of cultured microglia.Expression of a pro−apoptotic protein, Bax, but not Bcl−2, was increased by the serum deprivation.SB203580, a specific inhibitor of p38MAPK, prevented both the serum deprivation−induced Bax expression and microglial death.Immunochemical staining showed that microglia expressing a high level of Bax were subjected to apoptosis−like cell death.These observations suggest that Bax expression underlies the apoptosis of cultured microglia after serum deprivation.
- 社団法人 日本薬理学会の論文
- 2000-08-01
著者
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HASHIMOTO Hitoshi
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka Univers
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Baba A
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Baba A
Laboratory Of Molecular Neuropharmacology
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Baba Akemichi
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Baba Akemichi
昭和大学藤が丘病院 循環器内科
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Baba A
昭和大学藤が丘病院 循環器内科
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Baba A
Osaka Univ. Osaka Jpn
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Baba Akemichi
サントリー生物医学研究所
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Matsuda T
Lab. Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka Univ.
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MATSUDA Toshio
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
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KOYAMA Yutaka
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
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Koyama Yutaka
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Yoshioka Yasuhiro
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Hashimoto Hitoshi
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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KIMURA Yuji
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka Univers
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WAKAMATSU Daisuke
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka Univers
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KOZAKI Ryo-hei
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka Univers
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Wakamatsu Daisuke
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Kimura Yoshiyuki
New Drug Research Department High Quality-life Research Laboratories Bio-medical Division Sumitomo M
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Matsuda Toshio
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Kimura Yuji
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Baba Akemichi
Laboratory Of Molecular Neuropharmacology
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Kozaki Ryo-hei
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Kimura Yuji
Laboratory Of Entomology Faculty Of Agriculture And Life Science Hirosaki University:(present Addres
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Baba Akemichi
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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