Protective Effect of T-588 on Toxic Damage by Serum Deprivation and Amyloid-β Protein in Cultured Neurons
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概要
- 論文の詳細を見る
The present study examines the effect of the cognition enhancer (1R)-1-benzo[b]thiophen-5-yl-2-[2-(diethylamino)ethoxy]ethan-1-ol hydrochloride (T-588) on neuronal injury induced by serum deprivation or amyloid-β protein (Aβ). T-588 protected partially against neuronal injury induced by serum deprivation or Aβ in cultured cortical neurons. T-588 did not affect the phosphorylation of extracellular signal-regulated kinase (ERK) in cortical neurons and SH-SY5Y cells. These results suggest that T-588 has a protective effect in neuronal injury models and the effect is not mediated by an ERK signal pathway.
- 社団法人 日本薬理学会の論文
- 2003-06-01
著者
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Maeda Sadaaki
Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, Japan
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Yamamuro Akiko
摂南大学 薬学部薬物治療学
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Yamamuro Akiko
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Baba A
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Baba Akemichi
Lab. Of Veterinary Pharmacology Graduate School Of Life And Environmental Sci. Osaka Prefecture Univ
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Baba A
Laboratory Of Molecular Neuropharmacology
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Baba Akemichi
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Baba Akemichi
昭和大学藤が丘病院 循環器内科
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Baba A
昭和大学藤が丘病院 循環器内科
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Baba A
Osaka Univ. Osaka Jpn
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Baba Akemichi
サントリー生物医学研究所
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Matsuda T
Lab. Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka Univ.
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AGO Yukio
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
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MATSUDA Toshio
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
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SAKAI Yoshiyuki
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka Univers
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SAKAUE Mzsaki
Laboratory of Molecular Neuropharmacology
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Sakai Yoshiyuki
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Matsuda Toshio
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Baba Akemichi
Laboratory Of Molecular Neuropharmacology
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Ago Yukio
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Maeda Sadaaki
Department Of Pharmacotherapeutics Faculty Of Pharmaceutical Sciences Setsunan University
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Maeda Sadaaki
Department Of Pharmacology Faculty Of Dentistry Osaka University
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Baba Akemichi
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Sato Maiko
Lab. Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka Univ. Jpn
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