Role of Na+/Ca2+ Exchanger–Mediated Ca2+ Entry in Pressure-Induced Myogenic Constriction in Rat Posterior Cerebral Arteries
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概要
- 論文の詳細を見る
The involvement of Ca2+ entry via the Na+/Ca2+ exchanger (NCX) in myogenic constriction of rat posterior cerebral arteries was investigated. RT-PCR identified mRNA for NCX1, 2, and 3 in the arteries. Na+ removal increased [Ca2+]i, which was reduced by the NCX inhibitor SEA0400. SEA0400 inhibited the development, but not the steady-state, of pressure-induced myogenic constriction, whereas it decreased both the initial and sustained phases of [Ca2+]i elevation. These results suggest that Ca2+ entry via NCX is involved in the development, but not the steady-state, of pressure-induced myogenic constriction.
- 社団法人 日本薬理学会の論文
著者
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Baba Akemichi
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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MATSUDA Toshio
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
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ISHIKAWA Tomohisa
Department of Neuropsychiatry, Ehime University Medical School
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KASHIHARA Toshihide
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, University of Shizuoka
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NAKAYAMA Koichi
Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Iwate Medical
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Matsuda Toshio
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Baba Akemichi
Laboratory Of Molecular Neuropharmacology
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Nakayama Koichi
Department Of Molecular And Cellular Pharmacology Faculty Of Pharmaceutical Sciences Iwate Medical U
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Nakayama Koichi
Department Of Cellular And Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Univers
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Ishikawa Tomohisa
Department Of Cellular And Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Univers
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Kashihara Toshihide
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences University Of Shizuoka
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Kashihara Toshihide
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Ishikawa Tomohisa
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Japan
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Nakayama Koichi
Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Iwate Medical University, Japan
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