ANTIARRHYTHMIC POTENCY OF N-PROPYL AJMALINE WITH UNTOWARD RESPONSE OF VENTRICULAR FIBRILLATION IN EXCESS DOSE
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概要
- 論文の詳細を見る
The antiarrhythmic activities of N-propyl ajmaline was evaluated in anesthetized dogs. N-propyl ajmaline was effective on aconitine-induced atrial and ouabain-induced ventricular arrhythmias. Antiarrhythmic activity of N-propyl ajmaline was ten times more potent than that of ajmaline. Rapid infusion of N-propyl ajmaline induced ventricular flutter and fibrillation, but these effects were abolished by pre-treatment with β-adrenergic blocking agent.
- 公益社団法人 日本薬理学会の論文
著者
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Oshima Takeshi
Department Of Otolaryngology Tohoku University School Of Medicine
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Koike Hiroyuki
Department Of Cardiovascular Surgery Japanese Red Cross Society Wakayama Medical Center
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Nakayama Koichi
Department Of Cellular And Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Univers
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KOIKE Hiroyuki
Department of Pharmacology and Experimental Therapeutics, School of Medicine, Tohoku University
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HASHIMOTO Koroku
Department of Pharmacology and Experimental Therapeutics, School of Medicine, Tohoku University
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