PHARMACOLOGIC ANALYSIS OF THE RESPONSE TO THYMOXAMINE (6-ACETOXYTHYMOXY-ETHYL-DIMETHYLAMINE) ON THE SINOATRIAL NODE OF THE DOG HEART
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概要
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Using in situ constant pressure perfusion of the SA node artery at 100 mmHg, the effect of thymoxamine, which is a salt of (6-acetoxythymoxy) ethyldimethylamine, was investigated in 7 vagotomized dogs weighing 9 to 15 kg. Thymoxamine injected into the SA node artery induced a biphasic chronotropic response, i.e. a deceleration of sinus rate followed by an acceleration. The threshold dose for induction of sinus deceleration by thymoxamine was 3 to 10 μg. This deceleration response was not influenced by atropine treatment. The threshold dose for induction of sinus acceleration by thymoxamine was 10 to 30 μg. This accelerated response was inhibited by propranolol or tetrodotoxin. These results indicate that thymoxamine induces direct depressive action on the SA node pacemaker and the acceleration due to catecholamine release accompanying excitation of sympathetic nerve fibers in the SA node region.
- 公益社団法人 日本薬理学会の論文
著者
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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CHIBA Shigetoshi
Department of Pharmacology, Tohoku University School of Medicine
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OGURO Katsunori
Department of Pharmacology and Experimental Therapeutics, Tohoku University School of Medicine
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HASHIMOTO Koroku
Department of Pharmacology and Experimental Therapeutics, School of Medicine, Tohoku University
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