COMPARISON OF THE EFFECTS OF NOREPINEPHRINE AND ACETYLCHOLINE BETWEEN INTRAARTERIAL AND EXTRAVASCULAR ADMINISTRATION TO THE ISOLATED, BLOOD-PERFUSED CANINE ATRIUM
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概要
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Effects of acetylcholine (ACh) and norepinephrine on atrial contractility and pacemaker activity were investigated in isolated and blood-perfused canine atrium preparations with a support dog which were suspended in the blood-filled bath kept at 37°C. The drug was given in two forms of administration, <I>i.e</I>., intraarterial injection into the cannulated sinus node artery or direct administration into the bath. ACh administered into the bath produced a significant decrease in the developed tension from a concentration of 10-5 g, ml and norepinephrine produced a significant increase in the developed tension from 3×10<SUP>-6</SUP> g/ml. An injection <I>via</I> the sinus node artery resulted in 300 and 100 times greater response to ACh and norepinephrine, respectively, in the tension development. In atrial pacemaker activity, ACh given into the bath did not produce a dose-related decrease while norepinephrine produced a dose-related increase frequently accompanied by an irregularity of rhythmicity.
- 社団法人 日本薬理学会の論文
著者
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Chiba Shigetoshi
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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HASHIMOTO Koroku
Department of Pharmacology, Tokyo University
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YABUUCHI Youichi
Department of Pharmacology, Tohoku University School of Medicine
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Hashimoto Koroku
Department Of Pharmacology Faculty Of Medicine University Of Tokyo:iatrochemical Institute Of The Ph
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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HASHIMOTO Koroku
Department of Pharmacology and Experimental Therapeutics, School of Medicine, Tohoku University
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