PRIMARY EFFECT OF GLUCAGON ON POSITIVE CHRONOTROPISM
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概要
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Chronotropic and inotropic effects of glucagon were compared with those of norepinephrine using the excised SA node and the papillary muscle preparations cross-circulated with a donor dog. Glucagon was administered i.v. to the donor dog at doses of 1 to 30 μg/kg, which caused a marked chronotropic but less marked inotropic effect. Cardiohemodynamic response to glucagon of anesthetized dogs was simulated by an acceleration induced by atrial pacing. It was concluded that glucagon is more effective on chronotropism than on inotropism, and that its cardiohemodynamic effects are mainly ascribed to the increased heart rate.
- 社団法人 日本薬理学会の論文
著者
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Kimura Tomohiko
Department Of Elctro-photo-optics Faculty Of Engineering Tokai University
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HASHIMOTO Koroku
Department of Pharmacology, Tokyo University
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KOKUBUN Masaru
Department of Pharmacology and Experimental Therapeutics, Tohoku University School of Medicine
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HASHIMOTO Koroku
Department of Pharmacology and Experimental Therapeutics, School of Medicine, Tohoku University
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KIMURA Tomohiko
Department of Pharmacology and Experimental Therapeutics, Tohoku University School of Medicine
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Kimura Tomohiko
Department of Chemistry, Faculty of Science, The University of Tokyo
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