EFFECT OF MANGANESE IONS ON THE CONTRACTION AND AUTOMATICITY OF THE BLOOD-PERFUSED CANINE PAPILLARY MUSCLE
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概要
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Effect of manganese ions (Mn) on the mammalian ventricular myocardium was investigated using the isolated blood-perfused papillary muscle from the canine right ventricle. Mn caused dose-dependently an increase in blood flow above 0.1 mg and negative inotropic and chronotropic effects above 0.3 mg, while there was little change in the configuration of EMG even at a dose of 30 mg of Mn. The effects of Mn on the contraction and blood flow of the papillary muscle preparation were reversible. Norepinephrine, caffeine and calcium induced a positive inotropic effect almost to the same extent in the control or in the depressed state after Mn treatment, while periarterial nerve stimulation definitely caused a diminished increase in the contractile force after Mn treatment. Furthermore, in the automatically beating papillary muscle the positive chronotropic responses to norepinephrine and periarterial nerve stimulation were more readily blocked by Mn than the positive isotropic ones. These observations suggest that Mn affects not only contraction but also catecholamine release and pacemaker potential.
- 社団法人 日本薬理学会の論文
著者
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Endoh Masao
Department of Cardiovascular Pharmacology, Yamagata University School of Medicine
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Kimura Tomohiko
Department Of Elctro-photo-optics Faculty Of Engineering Tokai University
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HASHIMOTO Koroku
Department of Pharmacology, Tokyo University
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Endoh Masao
Department Of Cardiovascular Pharmacology Yamagata University School Of Medicine
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Hashimoto Koroku
Department Of Pharmacology Faculty Of Medicine University Of Tokyo:iatrochemical Institute Of The Ph
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ENDOH Masao
Department of Pharmacology and Experimental Therapeutics, Tohoku University School o f Medicine
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HASHIMOTO Koroku
Department of Pharmacology and Experimental Therapeutics, School of Medicine, Tohoku University
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HASHIMOTO Koroku
Department of Pharmacology and Experimental Therapeutics, Tohoku University School o f Medicine
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KIMURA Tomohiko
Department of Pharmacology and Experimental Therapeutics, Tohoku University School o f Medicine
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Kimura Tomohiko
Department of Chemistry, Faculty of Science, The University of Tokyo
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