Effect of Bethanechol, Methacholine and Carbachol on AV Conduction of the Dog Heart
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概要
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Using a direct in situ perfusion technique of the AV node artery, the effect of bethanechol, a selective muscarinic stimulant, was investigated in 18 mongrel dogs and compared with other muscarinic stimulants, methacholine and carbachol which are used clinically. The injection of bethanechol into the AV node artery induced various degrees of AV block. The threshold dose was 1 to 3μg. for inducing a second degree of AV block. More than 10μg. of bethanechol induced long lasting complete AV block. When complete AV block was induced, a constant rate of 32±2.1 (mean±S.E.) beats/min. of nodal rhythm was obtained in 15 cases. During complete AV block, atrial fibrillation was occasionally induced and also ventricular tachycardia at a rate of 110±5.8 (mean±S.E.) beats/min. (n=11). These effects of bethanechol were similar to those of methacholine or carbachol.
- International Heart Journal刊行会の論文
著者
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Hashimoto Koroku
Department Of Pharmacology Faculty Of Medicine University Of Tokyo:iatrochemical Institute Of The Ph
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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KUBOTA Katsumi
Department of Pharmacology, School of Medicine, Tohoku University
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HASHIMOTO Koroku
Department of Pharmacology and Experimental Therapeutics, School of Medicine, Tohoku University
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