Effects of Magnesium on the Isolated, Blood-Perfused Atrial and Ventricular Preparations of the Dog Heart
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概要
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The effects of magnesium chloride were investigated on pacemaker activity and atrial contractility, using isolated, blood-perfused canine atrial and ventricular preparations with heparinized arterial blood led from the support dogs. Magnesium chloride injected directly into the sinus node artery produced dose-related negative chronotropic and inotropic effects in isolated right atria. In small doses (0.1-1mg), magnesium chloride caused only a negative chronotropic effect without significant negative inotropic changes. The threshold dose for inducing the negative chronotropic response to magnesium chloride was approximately 0.3-1mg, but that for the negative inotropic response 1-3mg. The duration of the negative inotropic response was usually shorter than that of the negative chronotropic response. These negative effects were not inhibited by atropine which completely blocked the acetylcholineinduced effects. Magnesium chloride also produced a dose-dependent negative inotropic effect in the isolated, blood-perfused left ventricular preparation in relatively high dose ranges. Moreover, magnesium chloride produced an uniform depression of contraction amplitude at all frequencies (2-3.5Hz) examined on the frequency-force relationship.
- International Heart Journal刊行会の論文
著者
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Chiba Shigetoshi
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Furukawa Yasuyuki
Department Of Pharmacology Shinshu University School Of Medicine
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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CHIBA Shigetoshi
Department of Pharmacology, Faculty of Medicine, Shinshu University
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