Inotropic and chronotropic activity of a new cardiotonic agent, DM 9278 (1,2,3,4,8,9,10,12-octahydro(2,1-b)pyrido(2,3-f)qunazolin-9-one), on isolated dog atrial and ventricular muscles.
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概要
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The cardiac effects of DM9278 were studied in isolated and blood-perfused atrial and ventricular preparations from mongrel dogs. In spontaneously beating isolated right atria, DM9278 caused positive chronotropic and inotropic responses in a dose-related manner (1-100μg). DM9278 produced relatively larger positive inotropic than positive chronotropic effects as compared with effects of aminophylline or papaverine. DM9278 increased the developed tension in left ventricles electrically driven at 1.5 -2.0Hz. Positive inotropic and chronotropic responses to DM9278 in both atrial and ventricular preparations were suppressed slightly but not significantly by 1-3μg of propranolol, which completely blocked the positive chronotropic and inotropic effects of norepinephrine (0.01-0.1μg). From these results, it is concluded that DM9278 has direct cardiotonic properties in isolated dog heart tissues, showing relatively selective positive inotropic activity.
- International Heart Journal刊行会の論文
著者
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Furukawa Yasuyuki
Department Of Pharmacology Shinshu University School Of Medicine
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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SAEGUSA Kimiaki
Department of Pharmacology and Research Laboratory for Cardiovascular Diseases, Shinshu University School of Medicine
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OGIWARA Yasuhiro
Department of Pharmacology, Shinshu University School of Medicine
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