Perivascular Purinergic Nerve-Induced Vasoconstrictions in Canine Isolated Splenic Arteries
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概要
- 論文の詳細を見る
We tried to induce selective perivascular purinergic nerve stimulation in isolated canine splenic arterial preparations, using the cannula insertion method.Under the conditions of periarterial electrical stimulation(ES), i.e., trains of 1, 3 and 10 pulses, 1−ms pulse duration and 10−V amplitude at 1 Hz, monophasic vasoconstriction was consistently induced.The ES−induced vasoconstriction was not influenced by prazosin in doses that completely inhibited noradrenaline−induced vasoconstrictions, but it was suppressed by α, β−methylene ATP, a P2X purinoceptor desensitizer.Thus, it is indicated that a selective purinergic transmitter release is readily obtained in the isolated splenic arterial preparation.
- 社団法人 日本薬理学会の論文
- 2000-01-01
著者
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Yang Xiao-ping
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Chiba Shigetoshi
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Yang Xiao-ping
Departmen T Of Pharmacology Shinshu University School Of Medicine
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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