Cardiovascular effects of dibutyryl cyclic AMP in the intact dog heart and the isolated cross-perfused right atrium.
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概要
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This study used an isolated right atrial preparation, crossperfused with arterial blood from a support dog. We investigated the effects of dibutyryl cyclic AMP (DBcAMP) on heart rate and arterial blood pressure of the support dog and on the sinus rate and atrial contractile force of the isolated perfused atrium. DBcAMP was injected into the external jugular vein of the support dog or into the sinus node artery of the isolated atrium. DBcAMP to the support dog induced a small increase and/or decrease in arterial blood pressure at a dose of 3 or 10mg/Kg i.v. It produced a decrease, with or without an increase in blood pressure, at a dose of 30mg/Kg i.v., and a dosedependent increase in heart rate in the support dog. In the isolated atrium, positive chronotropic and inotropic effects were observed. Direct injection of DBcAMP (3-30mg) into the sinus node artery of the isolated atrium induced positive chronotropic and inotropic effects, after initial brief negative effects, in a dosedependent manner. DBcAMP did not change norepinephrineinduced positive chronotropic and inotropic effects in the isolated atrium. These results demonstrate that DBcAMP induces a decrease in systemic arterial blood pressure with increases in sinus rate and atrial contractile force, and acts additively with the norepinephrineinduced positive cardiac effects in the dog heart.
- International Heart Journal刊行会の論文
著者
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Takeda Masayoshi
Department Of Mathematical Science Faculty Of Engineering Science Osaka University
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Furukawa Yasuyuki
Department Of Pharmacology Shinshu University School Of Medicine
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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Chiba Shigetoshi
Department of Pharmacology, Shinshu University School of Medicine
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SAEGUSA Kimiaki
Department of Pharmacology and Research Laboratory for Cardiovascular Diseases, Shinshu University School of Medicine
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OGIWARA Yasuhiro
Department of Pharmacology, Shinshu University School of Medicine
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