Different Chronotropic and Inotropic Effects of EMD 57033 and EMD 53998, Ca^<2+> Sensitizers, on Isolated, Blood-Perfused Dog Heart Preparations
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概要
- 論文の詳細を見る
To investigate whether a Ca2+ sensitizer increases sinus rate, we studied the effects of racemic thiadiazinone, EMD 53998 (a Ca2+ sensitizer with phosphodiesterase inhibitory action) and its (+)-enantiomer EMD 57033 (a relatively pure Ca2+ sensitizer) on isolated, blood-perfused spontaneously beating right atria and paced left ventricles of the dogs. EMD 53998 increased sinus rate dose-dependently, but EMD 57033 did not. Both substances increased atrial and ventricular contractile force. Propranolol did not affect the responses to each substance. These results suggest that the Ca2+ sensitizing action induced by EMD 57033 does not affect pacemaker currents directly.
- 社団法人 日本薬理学会の論文
- 1998-04-01
著者
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Lakhe Manoj
信州大学 薬理
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Lakhe Manoj
Department Of Pharmacology Shinshu University School Of Medicine
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Miyashita Yusuke
Department of Cardiology, Shonan Kamakura General Hospital
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Chiba Shigetoshi
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Hirose Masamichi
Department of Molecular Pharmacology, Shinshu University School of Medicine
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FURUKAWA Yasuyuki
Department of Pharmacology, Shinshu University School of Medicine
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Furukawa Yasuyuki
Department Of Pharmacology Shinshu University School Of Medicine
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NAGASHIMA YOSHITO
Department of Pharmacology, Shinshu University School of Medicine
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YONEZAWA Takanori
Department of Pharmacology, Shinshu University School of Medicine
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Chiba S
信州大学 薬理
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Yonezawa Takanori
Department Of Pharmacology Shinshu Unibersity School Of Medicine
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Yonezawa Takanori
Department Of Cardiology National Nagano Hospital
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Hirose Masamichi
Department Of Pharmacology Shinshu University School Of Medicine
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Hirose Masamichi
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Miyashita Yusuke
Department Of Pharmacology Shinshu University School Of Medicine
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Nagashima Y
Department Of Pharmacology Shinshu University School Of Medicine
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Hirose Masamichi
Department Of Molecular And Cellular Pharmacology Iwate Medical University School Of Pharmaceutical
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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MIYASHITA Yusuke
Department of Advanced PAD Therapeutics, Shinshu University
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